Leonie Ringrose

Picture of the Group Leader Leonie Ringrose

Epigenetic regulation by the Polycomb and Trithorax group proteins

  • How do different cell types remember their identities over many cell generations? Part of the answer lies in the Polycomb and Trithorax groups of proteins. The Polycomb (PcG) and Trithorax (TrxG) groups of proteins work antagonistically on the same target genes, to maintain repressed (PcG) or active (TrxG) transcription states. We use a combination of quantitative live imaging, mathematical modelling, computational approaches and molecular and developmental biology to understand the interaction of the Polycomb and Trithorax proteins with their chromatin targets. We aim to unravel this fascinating epigenetic gene regulatory system in terms of the design, function and dynamic behaviour of its components. Our goal is to understand how a system whose components are in constant flux can ensure both stability and flexibility of gene expression states.

Leonie Ringrose has moved her lab to the IRI for Life Sciences at the Humboldt University, Berlin. 



Selected Publications

Herzog, VA., Lempradl, A., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., Ruf, M., Pospisilik, A., Dimond, A., Senergin, HB., Vargas, ML., Simon, JA., Ringrose, L. (2014). A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet. 46(9):973-81 (abstract)
Steffen, PA., Ringrose, L. (2014). What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 15(5):340-56 (abstract)
Steffen, PA., Fonseca, JP., Gänger, C., Dworschak, E., Kockmann, T., Beisel, C., Ringrose, L. (2013). Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucleic Acids Res. 41(10):5235-50 (abstract)
Fonseca, JP., Steffen, PA., Müller, S., Lu, J., Sawicka, A., Seiser, C., Ringrose, L. (2012). In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes Dev. 26(8):857-71 (abstract)
Hekimoglu-Balkan, B., Aszodi, A., Heinen, R., Jaritz, M., Ringrose, L. (2012). Intergenic Polycomb target sites are dynamically marked by non-coding transcription during lineage commitment. RNA Biol. 9(3):314-25 (abstract)
Steffen, PA., Fonseca, JP., Ringrose, L. (2012). Epigenetics meets mathematics: towards a quantitative understanding of chromatin biology. Bioessays. 34(10):901-13 (abstract)
Okulski, H., Druck, B., Bhalerao, S., Ringrose, L. (2011). Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment. Epigenetics Chromatin. 4:4 (abstract)
Hekimoglu, B., Ringrose, L. (2009). Non-coding RNAs in polycomb/trithorax regulation. RNA Biol. 6(2):129-37 (abstract)
Hauenschild, A., Ringrose, L., Altmutter, C., Paro, R., Rehmsmeier, M. (2008). Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol. 6(10):e261 (abstract)
Lempradl, A., Ringrose, L. (2008). How does noncoding transcription regulate Hox genes? Bioessays. 30(2):110-21 (abstract)

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