Publications

(2017)
 
Galluzzi, L., Baehrecke, EH., Ballabio, A., Boya, P., Bravo-San Pedro, JM., Cecconi, F., Choi, AM., Chu, CT., Codogno, P., Colombo, MI., Cuervo, AM., Debnath, J., Deretic, V., Dikic, I., Eskelinen, EL., Fimia, GM., Fulda, S., Gewirtz, DA., Green, DR., Hansen, M., Harper, JW., Jäättelä, M., Johansen, T., Juhasz, G., Kimmelman, AC., Kraft, C., Ktistakis, NT., Kumar, S., Levine, B., Lopez-Otin, C., Madeo, F., Martens, S., Martinez, J., Melendez, A., Mizushima, N., Münz, C., Murphy, LO., Penninger, JM., Piacentini, M., Reggiori, F., Rubinsztein, DC., Ryan, KM., Santambrogio, L., Scorrano, L., Simon, AK., Simon, HU., Simonsen, A., Tavernarakis, N., Tooze, SA., Yoshimori, T., Yuan, J., Yue, Z., Zhong, Q., Kroemer, G. (2017). Molecular definitions of autophagy and related processes. EMBO J. (abstract)
 
Kiechl, S., Schramek, D., Widschwendter, M., Fourkala, EO., Zaikin, A., Jones, A., Jaeger, B., Rack, B., Janni, W., Scholz, C., Willeit, J., Weger, S., Mayr, A., Teschendorff, A., Rosenthal, A., Fraser, L., Philpott, S., Dubeau, L., Keshtgar, M., Roylance, R., Jacobs, IJ., Menon, U., Schett, G., Penninger, JM. (2017). Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. 8(3):3811-3825 (abstract)
 
Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, JM., Nakashima, T., Takayanagi, H. (2017). Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol. (abstract)
 
Openshaw, RL., Thomson, DM., Penninger, JM., Pratt, JA., Morris, BJ. (2017). Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline. Psychopharmacology (Berl). 234(2):293-305 (abstract)
 
Sato, T., Sato, C., Kadowaki, A., Watanabe, H., Ho, L., Ishida, J., Yamaguchi, T., Kimura, A., Fukamizu, A., Penninger, JM., Reversade, B., Ito, H., Imai, Y., Kuba, K. (2017). ELABELA - APJ axis protects from pressure overload heart failure and Angiotensin II-induced cardiac damage. Cardiovasc Res. (abstract)
 
Schneider, C., Nobs, SP., Heer, AK., Hirsch, E., Penninger, J., Siggs, OM., Kopf, M. (2017). Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. J Leukoc Biol. 101(2):367-376 (abstract)
 
Tsukasaki, M., Hamada, K., Okamoto, K., Nagashima, K., Terashima, A., Komatsu, N., Win, SJ., Okamura, T., Nitta, T., Yasuda, H., Penninger, JM., Takayanagi, H. (2017). LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res. 32(3):434-439 (abstract)
 
(2016)
 
Akiyama, N., Takizawa, N., Miyauchi, M., Yanai, H., Tateishi, R., Shinzawa, M., Yoshinaga, R., Kurihara, M., Demizu, Y., Yasuda, H., Yagi, S., Wu, G., Matsumoto, M., Sakamoto, R., Yoshida, N., Penninger, JM., Kobayashi, Y., Inoue, J., Akiyama, T. (2016). Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J Exp Med. 213(8):1441-58 (abstract)
 
Andritschke, D., Dilling, S., Emmenlauer, M., Welz, T., Schmich, F., Misselwitz, B., Rämö, P., Rottner, K., Kerkhoff, E., Wada, T., Penninger, JM., Beerenwinkel, N., Horvath, P., Dehio, C., Hardt, WD. (2016). A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. PLoS One. 11(9):e0161965 (abstract)
 
Dalgaard, K., Landgraf, K., Heyne, S., Lempradl, A., Longinotto, J., Gossens, K., Ruf, M., Orthofer, M., Strogantsev, R., Selvaraj, M., Lu, TT., Casas, E., Teperino, R., Surani, MA., Zvetkova, I., Rimmington, D., Tung, YC., Lam, B., Larder, R., Yeo, GS., O'Rahilly, S., Vavouri, T., Whitelaw, E., Penninger, JM., Jenuwein, T., Cheung, CL., Ferguson-Smith, AC., Coll, AP., Körner, A., Pospisilik, JA. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164(3):353-64 (abstract)
 
Dufresne, SS., Dumont, NA., Boulanger-Piette, A., Fajardo, VA., Gamu, D., Kake-Guena, SA., David, RO., Bouchard, P., Lavergne, É., Penninger, JM., Pape, PC., Tupling, AR., Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. Am J Physiol Cell Physiol. 310(8):C663-72 (abstract)
 
Einwallner, E., Kiefer, FW., Di Caro, G., Orthofer, M., Witzeneder, N., Hörmann, G., Itariu, B., Zeyda, M., Penninger, JM., Stulnig, TM., Esterbauer, H., Todoric, J. (2016). Mast cells are not associated with systemic insulin resistance. Eur J Clin Invest. 46(11):911-919 (abstract)
 
Haubner, BJ., Schneider, J., Schweigmann, U., Schuetz, T., Dichtl, W., Velik-Salchner, C., Stein, JI., Penninger, JM. (2016). Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circ Res. 118(2):216-21 (abstract)
 
Haubner, BJ., Schuetz, T., Penninger, JM. (2016). A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Res Cardiol. 111(6):64 (abstract)
 
Iwamoto, Y., Nishikawa, K., Imai, R., Furuya, M., Uenaka, M., Ohta, Y., Morihana, T., Itoi-Ochi, S., Penninger, JM., Katayama, I., Inohara, H., Ishii, M. (2016). Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction. Mol Cell Biol. 36(11):1610-20 (abstract)
 
Klionsky, DJ., Abdelmohsen, K., Abe, A., Abedin, MJ., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, CM., Adams, PD., Adeli, K., Adhihetty, PJ., Adler, SG., Agam, G., Agarwal, R., Aghi, MK., Agnello, M., Agostinis, P., Aguilar, PV., Aguirre-Ghiso, J., Airoldi, EM., Ait-Si-Ali, S., Akematsu, T., Akporiaye, ET., Al-Rubeai, M., Albaiceta, GM., Albanese, C., Albani, D., Albert, ML., Aldudo, J., Algül, H., Alirezaei, M., Alloza, I., Almasan, A., Almonte-Beceril, M., Alnemri, ES., Alonso, C., Altan-Bonnet, N., Altieri, DC., Alvarez, S., Alvarez-Erviti, L., Alves, S., Amadoro, G., Amano, A., Amantini, C., Ambrosio, S., Amelio, I., Amer, AO., Amessou, M., Amon, A., An, Z., Anania, FA., Andersen, SU., Andley, UP., Andreadi, CK., Andrieu-Abadie, N., Anel, A., Ann, DK., Anoopkumar-Dukie, S., Antonioli, M., Aoki, H., Apostolova, N., Aquila, S., Aquilano, K., Araki, K., Arama, E., Aranda, A., Araya, J., Arcaro, A., Arias, E., Arimoto, H., Ariosa, AR., Armstrong, JL., Arnould, T., Arsov, I., Asanuma, K., Askanas, V., Asselin, E., Atarashi, R., Atherton, SS., Atkin, JD., Attardi, LD., Auberger, P., Auburger, G., Aurelian, L., Autelli, R., Avagliano, L., Avantaggiati, ML., Avrahami, L., Awale, S., Azad, N., Bachetti, T., Backer, JM., Bae, DH., Bae, JS., Bae, ON., Bae, SH., Baehrecke, EH., Baek, SH., Baghdiguian, S., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, XY., Bailly, Y., Balaji, KN., Balduini, W., Ballabio, A., Balzan, R., Banerjee, R., Bánhegyi, G., Bao, H., Barbeau, B., Barrachina, MD., Barreiro, E., Bartel, B., Bartolomé, A., Bassham, DC., Bassi, MT., Bast, RC., Basu, A., Batista, MT., Batoko, H., Battino, M., Bauckman, K., Baumgarner, BL., Bayer, KU., Beale, R., Beaulieu, JF., Beck, GR., Becker, C., Beckham, JD., Bédard, PA., Bednarski, PJ., Begley, TJ., Behl, C., Behrends, C., Behrens, GM., Behrns, KE., Bejarano, E., Belaid, A., Belleudi, F., Bénard, G., Berchem, G., Bergamaschi, D., Bergami, M., Berkhout, B., Berliocchi, L., Bernard, A., Bernard, M., Bernassola, F., Bertolotti, A., Bess, AS., Besteiro, S., Bettuzzi, S., Bhalla, S., Bhattacharyya, S., Bhutia, SK., Biagosch, C., Bianchi, MW., Biard-Piechaczyk, M., Billes, V., Bincoletto, C., Bingol, B., Bird, SW., Bitoun, M., Bjedov, I., Blackstone, C., Blanc, L., Blanco, GA., Blomhoff, HK., Boada-Romero, E., Böckler, S., Boes, M., Boesze-Battaglia, K., Boise, LH., Bolino, A., Boman, A., Bonaldo, P., Bordi, M., Bosch, J., Botana, LM., Botti, J., Bou, G., Bouché, M., Bouchecareilh, M., Boucher, MJ., Boulton, ME., Bouret, SG., Boya, P., Boyer-Guittaut, M., Bozhkov, PV., Brady, N., Braga, VM., Brancolini, C., Braus, GH., Bravo-San Pedro, JM., Brennan, LA., Bresnick, EH., Brest, P., Bridges, D., Bringer, MA., Brini, M., Brito, GC., Brodin, B., Brookes, PS., Brown, EJ., Brown, K., Broxmeyer, HE., Bruhat, A., Brum, PC., Brumell, JH., Brunetti-Pierri, N., Bryson-Richardson, RJ., Buch, S., Buchan, AM., Budak, H., Bulavin, DV., Bultman, SJ., Bultynck, G., Bumbasirevic, V., Burelle, Y., Burke, RE., Burmeister, M., Bütikofer, P., Caberlotto, L., Cadwell, K., Cahova, M., Cai, D., Cai, J., Cai, Q., Calatayud, S., Camougrand, N., Campanella, M., Campbell, GR., Campbell, M., Campello, S., Candau, R., Caniggia, I., Cantoni, L., Cao, L., Caplan, AB., Caraglia, M., Cardinali, C., Cardoso, SM., Carew, JS., Carleton, LA., Carlin, CR., Carloni, S., Carlsson, SR., Carmona-Gutierrez, D., Carneiro, LA., Carnevali, O., Carra, S., Carrier, A., Carroll, B., Casas, C., Casas, J., Cassinelli, G., Castets, P., Castro-Obregon, S., Cavallini, G., Ceccherini, I., Cecconi, F., Cederbaum, AI., Ceña, V., Cenci, S., Cerella, C., Cervia, D., Cetrullo, S., Chaachouay, H., Chae, HJ., Chagin, AS., Chai, CY., Chakrabarti, G., Chamilos, G., Chan, EY., Chan, MT., Chandra, D., Chandra, P., Chang, CP., Chang, RC., Chang, TY., Chatham, JC., Chatterjee, S., Chauhan, S., Che, Y., Cheetham, ME., Cheluvappa, R., Chen, CJ., Chen, G., Chen, GC., Chen, G., Chen, H., Chen, JW., Chen, JK., Chen, M., Chen, M., Chen, P., Chen, Q., Chen, Q., Chen, SD., Chen, S., Chen, SS., Chen, W., Chen, WJ., Chen, WQ., Chen, W., Chen, X., Chen, YH., Chen, YG., Chen, Y., Chen, Y., Chen, Y., Chen, YJ., Chen, YQ., Chen, Y., Chen, Z., Chen, Z., Cheng, A., Cheng, CH., Cheng, H., Cheong, H., Cherry, S., Chesney, J., Cheung, CH., Chevet, E., Chi, HC., Chi, SG., Chiacchiera, F., Chiang, HL., Chiarelli, R., Chiariello, M., Chieppa, M., Chin, LS., Chiong, M., Chiu, GN., Cho, DH., Cho, SG., Cho, WC., Cho, YY., Cho, YS., Choi, AM., Choi, EJ., Choi, EK., Choi, J., Choi, ME., Choi, SI., Chou, TF., Chouaib, S., Choubey, D., Choubey, V., Chow, KC., Chowdhury, K., Chu, CT., Chuang, TH., Chun, T., Chung, H., Chung, T., Chung, YL., Chwae, YJ., Cianfanelli, V., Ciarcia, R., Ciechomska, IA., Ciriolo, MR., Cirone, M., Claerhout, S., Clague, MJ., Clària, J., Clarke, PG., Clarke, R., Clementi, E., Cleyrat, C., Cnop, M., Coccia, EM., Cocco, T., Codogno, P., Coers, J., Cohen, EE., Colecchia, D., Coletto, L., Coll, NS., Colucci-Guyon, E., Comincini, S., Condello, M., Cook, KL., Coombs, GH., Cooper, CD., Cooper, JM., Coppens, I., Corasaniti, MT., Corazzari, M., Corbalan, R., Corcelle-Termeau, E., Cordero, MD., Corral-Ramos, C., Corti, O., Cossarizza, A., Costelli, P., Costes, S., Cotman, SL., Coto-Montes, A., Cottet, S., Couve, E., Covey, LR., Cowart, LA., Cox, JS., Coxon, FP., Coyne, CB., Cragg, MS., Craven, RJ., Crepaldi, T., Crespo, JL., Criollo, A., Crippa, V., Cruz, MT., Cuervo, AM., Cuezva, JM., Cui, T., Cutillas, PR., Czaja, MJ., Czyzyk-Krzeska, MF., Dagda, RK., Dahmen, U., Dai, C., Dai, W., Dai, Y., Dalby, KN., Dalla Valle, L., Dalmasso, G., D'Amelio, M., Damme, M., Darfeuille-Michaud, A., Dargemont, C., Darley-Usmar, VM., Dasarathy, S., Dasgupta, B., Dash, S., Dass, CR., Davey, HM., Davids, LM., Dávila, D., Davis, RJ., Dawson, TM., Dawson, VL., Daza, P., de Belleroche, J., de Figueiredo, P., de Figueiredo, RC., de la Fuente, J., De Martino, L., De Matteis, A., De Meyer, GR., De Milito, A., De Santi, M., de Souza, W., De Tata, V., De Zio, D., Debnath, J., Dechant, R., Decuypere, JP., Deegan, S., Dehay, B., Del Bello, B., Del Re, DP., Delage-Mourroux, R., Delbridge, LM., Deldicque, L., Delorme-Axford, E., Deng, Y., Dengjel, J., Denizot, M., Dent, P., Der, CJ., Deretic, V., Derrien, B., Deutsch, E., Devarenne, TP., Devenish, RJ., Di Bartolomeo, S., Di Daniele, N., Di Domenico, F., Di Nardo, A., Di Paola, S., Di Pietro, A., Di Renzo, L., DiAntonio, A., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, MT., Diaz-Nido, J., Dickey, CA., Dickson, RC., Diederich, M., Digard, P., Dikic, I., Dinesh-Kumar, SP., Ding, C., Ding, WX., Ding, Z., Dini, L., Distler, JH., Diwan, A., Djavaheri-Mergny, M., Dmytruk, K., Dobson, RC., Doetsch, V., Dokladny, K., Dokudovskaya, S., Donadelli, M., Dong, XC., Dong, X., Dong, Z., Donohue, TM., Doran, KS., D'Orazi, G., Dorn, GW., Dosenko, V., Dridi, S., Drucker, L., Du, J., Du, LL., Du, L., du Toit, A., Dua, P., Duan, L., Duann, P., Dubey, VK., Duchen, MR., Duchosal, MA., Duez, H., Dugail, I., Dumit, VI., Duncan, MC., Dunlop, EA., Dunn, WA., Dupont, N., Dupuis, L., Durán, RV., Durcan, TM., Duvezin-Caubet, S., Duvvuri, U., Eapen, V., Ebrahimi-Fakhari, D., Echard, A., Eckhart, L., Edelstein, CL., Edinger, AL., Eichinger, L., Eisenberg, T., Eisenberg-Lerner, A., Eissa, NT., El-Deiry, WS., El-Khoury, V., Elazar, Z., Eldar-Finkelman, H., Elliott, CJ., Emanuele, E., Emmenegger, U., Engedal, N., Engelbrecht, AM., Engelender, S., Enserink, JM., Erdmann, R., Erenpreisa, J., Eri, R., Eriksen, JL., Erman, A., Escalante, R., Eskelinen, EL., Espert, L., Esteban-Martínez, L., Evans, TJ., Fabri, M., Fabrias, G., Fabrizi, C., Facchiano, A., Færgeman, NJ., Faggioni, A., Fairlie, WD., Fan, C., Fan, D., Fan, J., Fang, S., Fanto, M., Fanzani, A., Farkas, T., Faure, M., Favier, FB., Fearnhead, H., Federici, M., Fei, E., Felizardo, TC., Feng, H., Feng, Y., Feng, Y., Ferguson, TA., Fernández, ÁF., Fernandez-Barrena, MG., Fernandez-Checa, JC., Fernández-López, A., Fernandez-Zapico, ME., Feron, O., Ferraro, E., Ferreira-Halder, CV., Fesus, L., Feuer, R., Fiesel, FC., Filippi-Chiela, EC., Filomeni, G., Fimia, GM., Fingert, JH., Finkbeiner, S., Finkel, T., Fiorito, F., Fisher, PB., Flajolet, M., Flamigni, F., Florey, O., Florio, S., Floto, RA., Folini, M., Follo, C., Fon, EA., Fornai, F., Fortunato, F., Fraldi, A., Franco, R., Francois, A., François, A., Frankel, LB., Fraser, ID., Frey, N., Freyssenet, DG., Frezza, C., Friedman, SL., Frigo, DE., Fu, D., Fuentes, JM., Fueyo, J., Fujitani, Y., Fujiwara, Y., Fujiya, M., Fukuda, M., Fulda, S., Fusco, C., Gabryel, B., Gaestel, M., Gailly, P., Gajewska, M., Galadari, S., Galili, G., Galindo, I., Galindo, MF., Galliciotti, G., Galluzzi, L., Galluzzi, L., Galy, V., Gammoh, N., Gandy, S., Ganesan, AK., Ganesan, S., Ganley, IG., Gannagé, M., Gao, FB., Gao, F., Gao, JX., García Nannig, L., García Véscovi, E., Garcia-Macía, M., Garcia-Ruiz, C., Garg, AD., Garg, PK., Gargini, R., Gassen, NC., Gatica, D., Gatti, E., Gavard, J., Gavathiotis, E., Ge, L., Ge, P., Ge, S., Gean, PW., Gelmetti, V., Genazzani, AA., Geng, J., Genschik, P., Gerner, L., Gestwicki, JE., Gewirtz, DA., Ghavami, S., Ghigo, E., Ghosh, D., Giammarioli, AM., Giampieri, F., Giampietri, C., Giatromanolaki, A., Gibbings, DJ., Gibellini, L., Gibson, SB., Ginet, V., Giordano, A., Giorgini, F., Giovannetti, E., Girardin, SE., Gispert, S., Giuliano, S., Gladson, CL., Glavic, A., Gleave, M., Godefroy, N., Gogal, RM., Gokulan, K., Goldman, GH., Goletti, D., Goligorsky, MS., Gomes, AV., Gomes, LC., Gomez, H., Gomez-Manzano, C., Gómez-Sánchez, R., Gonçalves, DA., Goncu, E., Gong, Q., Gongora, C., Gonzalez, CB., Gonzalez-Alegre, P., Gonzalez-Cabo, P., González-Polo, RA., Goping, IS., Gorbea, C., Gorbunov, NV., Goring, DR., Gorman, AM., Gorski, SM., Goruppi, S., Goto-Yamada, S., Gotor, C., Gottlieb, RA., Gozes, I., Gozuacik, D., Graba, Y., Graef, M., Granato, GE., Grant, GD., Grant, S., Gravina, GL., Green, DR., Greenhough, A., Greenwood, MT., Grimaldi, B., Gros, F., Grose, C., Groulx, JF., Gruber, F., Grumati, P., Grune, T., Guan, JL., Guan, KL., Guerra, B., Guillen, C., Gulshan, K., Gunst, J., Guo, C., Guo, L., Guo, M., Guo, W., Guo, XG., Gust, AA., Gustafsson, ÅB., Gutierrez, E., Gutierrez, MG., Gwak, HS., Haas, A., Haber, JE., Hadano, S., Hagedorn, M., Hahn, DR., Halayko, AJ., Hamacher-Brady, A., Hamada, K., Hamai, A., Hamann, A., Hamasaki, M., Hamer, I., Hamid, Q., Hammond, EM., Han, F., Han, W., Handa, JT., Hanover, JA., Hansen, M., Harada, M., Harhaji-Trajkovic, L., Harper, JW., Harrath, AH., Harris, AL., Harris, J., Hasler, U., Hasselblatt, P., Hasui, K., Hawley, RG., Hawley, TS., He, C., He, CY., He, F., He, G., He, RR., He, XH., He, YW., He, YY., Heath, JK., Hébert, MJ., Heinzen, RA., Helgason, GV., Hensel, M., Henske, EP., Her, C., Herman, PK., Hernández, A., Hernandez, C., Hernández-Tiedra, S., Hetz, C., Hiesinger, PR., Higaki, K., Hilfiker, S., Hill, BG., Hill, JA., Hill, WD., Hino, K., Hofius, D., Hofman, P., Höglinger, GU., Höhfeld, J., Holz, MK., Hong, Y., Hood, DA., Hoozemans, JJ., Hoppe, T., Hsu, C., Hsu, CY., Hsu, LC., Hu, D., Hu, G., Hu, HM., Hu, H., Hu, MC., Hu, YC., Hu, ZW., Hua, F., Hua, Y., Huang, C., Huang, HL., Huang, KH., Huang, KY., Huang, S., Huang, S., Huang, WP., Huang, YR., Huang, Y., Huang, Y., Huber, TB., Huebbe, P., Huh, WK., Hulmi, JJ., Hur, GM., Hurley, JH., Husak, Z., Hussain, SN., Hussain, S., Hwang, JJ., Hwang, S., Hwang, TI., Ichihara, A., Imai, Y., Imbriano, C., Inomata, M., Into, T., Iovane, V., Iovanna, JL., Iozzo, RV., Ip, NY., Irazoqui, JE., Iribarren, P., Isaka, Y., Isakovic, AJ., Ischiropoulos, H., Isenberg, JS., Ishaq, M., Ishida, H., Ishii, I., Ishmael, JE., Isidoro, C., Isobe, K., Isono, E., Issazadeh-Navikas, S., Itahana, K., Itakura, E., Ivanov, AI., Iyer, AK., Izquierdo, JM., Izumi, Y., Izzo, V., Jäättelä, M., Jaber, N., Jackson, DJ., Jackson, WT., Jacob, TG., Jacques, TS., Jagannath, C., Jain, A., Jana, NR., Jang, BK., Jani, A., Janji, B., Jannig, PR., Jansson, PJ., Jean, S., Jendrach, M., Jeon, JH., Jessen, N., Jeung, EB., Jia, K., Jia, L., Jiang, H., Jiang, H., Jiang, L., Jiang, T., Jiang, X., Jiang, X., Jiang, X., Jiang, Y., Jiang, Y., Jiménez, A., Jin, C., Jin, H., Jin, L., Jin, M., Jin, S., Jinwal, UK., Jo, EK., Johansen, T., Johnson, DE., Johnson, GV., Johnson, JD., Jonasch, E., Jones, C., Joosten, LA., Jordan, J., Joseph, AM., Joseph, B., Joubert, AM., Ju, D., Ju, J., Juan, HF., Juenemann, K., Juhász, G., Jung, HS., Jung, JU., Jung, YK., Jungbluth, H., Justice, MJ., Jutten, B., Kaakoush, NO., Kaarniranta, K., Kaasik, A., Kabuta, T., Kaeffer, B., Kågedal, K., Kahana, A., Kajimura, S., Kakhlon, O., Kalia, M., Kalvakolanu, DV., Kamada, Y., Kambas, K., Kaminskyy, VO., Kampinga, HH., Kandouz, M., Kang, C., Kang, R., Kang, TC., Kanki, T., Kanneganti, TD., Kanno, H., Kanthasamy, AG., Kantorow, M., Kaparakis-Liaskos, M., Kapuy, O., Karantza, V., Karim, MR., Karmakar, P., Kaser, A., Kaushik, S., Kawula, T., Kaynar, AM., Ke, PY., Ke, ZJ., Kehrl, JH., Keller, KE., Kemper, JK., Kenworthy, AK., Kepp, O., Kern, A., Kesari, S., Kessel, D., Ketteler, R., Kettelhut, Ido C., Khambu, B., Khan, MM., Khandelwal, VK., Khare, S., Kiang, JG., Kiger, AA., Kihara, A., Kim, AL., Kim, CH., Kim, DR., Kim, DH., Kim, EK., Kim, HY., Kim, HR., Kim, JS., Kim, JH., Kim, JC., Kim, JH., Kim, KW., Kim, MD., Kim, MM., Kim, PK., Kim, SW., Kim, SY., Kim, YS., Kim, Y., Kimchi, A., Kimmelman, AC., Kimura, T., King, JS., Kirkegaard, K., Kirkin, V., Kirshenbaum, LA., Kishi, S., Kitajima, Y., Kitamoto, K., Kitaoka, Y., Kitazato, K., Kley, RA., Klimecki, WT., Klinkenberg, M., Klucken, J., Knævelsrud, H., Knecht, E., Knuppertz, L., Ko, JL., Kobayashi, S., Koch, JC., Koechlin-Ramonatxo, C., Koenig, U., Koh, YH., Köhler, K., Kohlwein, SD., Koike, M., Komatsu, M., Kominami, E., Kong, D., Kong, HJ., Konstantakou, EG., Kopp, BT., Korcsmaros, T., Korhonen, L., Korolchuk, VI., Koshkina, NV., Kou, Y., Koukourakis, MI., Koumenis, C., Kovács, AL., 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Z., Xavier, CP., Xavier, RJ., Xia, GX., Xia, T., Xia, W., Xia, Y., Xiao, H., Xiao, J., Xiao, S., Xiao, W., Xie, CM., Xie, Z., Xie, Z., Xilouri, M., Xiong, Y., Xu, C., Xu, C., Xu, F., Xu, H., Xu, H., Xu, J., Xu, J., Xu, J., Xu, L., Xu, X., Xu, Y., Xu, Y., Xu, ZX., Xu, Z., Xue, Y., Yamada, T., Yamamoto, A., Yamanaka, K., Yamashina, S., Yamashiro, S., Yan, B., Yan, B., Yan, X., Yan, Z., Yanagi, Y., Yang, DS., Yang, JM., Yang, L., Yang, M., Yang, PM., Yang, P., Yang, Q., Yang, W., Yang, WY., Yang, X., Yang, Y., Yang, Y., Yang, Z., Yang, Z., Yao, MC., Yao, PJ., Yao, X., Yao, Z., Yao, Z., Yasui, LS., Ye, M., Yedvobnick, B., Yeganeh, B., Yeh, ES., Yeyati, PL., Yi, F., Yi, L., Yin, XM., Yip, CK., Yoo, YM., Yoo, YH., Yoon, SY., Yoshida, K., Yoshimori, T., Young, KH., Yu, H., Yu, JJ., Yu, JT., Yu, J., Yu, L., Yu, WH., Yu, XF., Yu, Z., Yuan, J., Yuan, ZM., Yue, BY., Yue, J., Yue, Z., Zacks, DN., Zacksenhaus, E., Zaffaroni, N., Zaglia, T., Zakeri, Z., Zecchini, V., Zeng, J., Zeng, M., Zeng, Q., Zervos, AS., Zhang, DD., Zhang, F., Zhang, G., Zhang, GC., Zhang, H., Zhang, H., Zhang, H., Zhang, H., Zhang, J., Zhang, J., Zhang, J., Zhang, J., Zhang, JP., Zhang, L., Zhang, L., Zhang, L., Zhang, L., Zhang, MY., Zhang, X., Zhang, XD., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhao, M., Zhao, WL., Zhao, X., Zhao, YG., Zhao, Y., Zhao, Y., Zhao, YX., Zhao, Z., Zhao, ZJ., Zheng, D., Zheng, XL., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, GZ., Zhou, G., Zhou, H., Zhou, SF., Zhou, XJ., Zhu, H., Zhu, H., Zhu, WG., Zhu, W., Zhu, XF., Zhu, Y., Zhuang, SM., Zhuang, X., Ziparo, E., Zois, CE., Zoladek, T., Zong, WX., Zorzano, A., Zughaier, SM. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222 (abstract)
 
Luo, J., Yang, Z., Ma, Y., Yue, Z., Lin, H., Qu, G., Huang, J., Dai, W., Li, C., Zheng, C., Xu, L., Chen, H., Wang, J., Li, D., Siwko, S., Penninger, JM., Ning, G., Xiao, J., Liu, M. (2016). LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 22(5):539-46 (abstract)
 
Motta-Santos, D., Dos Santos, RA., Oliveira, M., Qadri, F., Poglitsch, M., Mosienko, V., Kappes Becker, L., Campagnole-Santos, MJ., M Penninger, J., Alenina, N., Bader, M. (2016). Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res. 39(7):506-12 (abstract)
 
Nunes-Souza, V., Alenina, N., Qadri, F., Penninger, JM., Santos, RA., Bader, M., Rabelo, LA. (2016). CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxid Med Cell Longev. 2016:6487509 (abstract)
 
Okamoto-Uchida, Y., Yu, R., Miyamura, N., Arima, N., Ishigami-Yuasa, M., Kagechika, H., Yoshida, S., Hosoya, T., Nawa, M., Kasama, T., Asaoka, Y., Alois, RW., Elling, U., Penninger, JM., Nishina, S., Azuma, N., Nishina, H. (2016). The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 6:37697 (abstract)
 
Paolino, M., Penninger, JM. (2016). The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy. Cancers (Basel). 8(10) (abstract)
 
Papanikos, F., Daniel, K., Goercharn-Ramlal, A., Fei, JF., Kurth, T., Wojtasz, L., Dereli, I., Fu, J., Penninger, J., Habermann, B., Surani, A., Stewart, AF., Toth, A. (2016). The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice. Chromosoma. (abstract)
 
Patel, VB., Mori, J., McLean, BA., Basu, R., Das, SK., Ramprasath, T., Parajuli, N., Penninger, JM., Grant, MB., Lopaschuk, GD., Oudit, GY. (2016). ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes. 65(1):85-95 (abstract)
 
Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, DP., Baracco, EE., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., Senovilla, L., Marino, G., Aranda, F., Durand, S., Sica, V., Chery, A., Lachkar, S., Sigl, V., Bloy, N., Buque, A., Falzoni, S., Ryffel, B., Apetoh, L., Di Virgilio, F., Madeo, F., Maiuri, MC., Zitvogel, L., Levine, B., Penninger, JM., Kroemer, G. (2016). Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30(1):147-60 (abstract)
 
Polizzotti, BD., Ganapathy, B., Haubner, BJ., Penninger, JM., Kühn, B. (2016). A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc. 11(3):542-52 (abstract)
 
Rabelo, LA., Todiras, M., Nunes-Souza, V., Qadri, F., Szijártó, IA., Gollasch, M., Penninger, JM., Bader, M., Santos, RA., Alenina, N. (2016). Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. PLoS One. 11(4):e0150255 (abstract)
 
Sigl, V., Jones, LP., Penninger, JM. (2016). RANKL/RANK: from bone loss to the prevention of breast cancer. Open Biol. 6(11) (abstract)
 
Sigl, V., Owusu-Boaitey, K., Joshi, PA., Kavirayani, A., Wirnsberger, G., Novatchkova, M., Kozieradzki, I., Schramek, D., Edokobi, N., Hersl, J., Sampson, A., Odai-Afotey, A., Lazaro, C., Gonzalez-Suarez, E., Pujana, MA., Cimba, F., Heyn, H., Vidal, E., Cruickshank, J., Berman, H., Sarao, R., Ticevic, M., Uribesalgo, I., Tortola, L., Rao, S., Tan, Y., Pfeiler, G., Lee, EY., Bago-Horvath, Z., Kenner, L., Popper, H., Singer, C., Khokha, R., Jones, LP., Penninger, JM. (2016). RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Res. 26(7):761-74 (abstract)
 
Tortola, L., Nitsch, R., Bertrand, MJ., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, LM., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Lang, M., Superti-Furga, G., Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 16(12):3414 (abstract)
 
Tortola, L., Nitsch, R., Bertrand, MJ., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, LM., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G., Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 15(7):1481-92 (abstract)
 
Valent, P., Groner, B., Schumacher, U., Superti-Furga, G., Busslinger, M., Kralovics, R., Zielinski, C., Penninger, JM., Kerjaschki, D., Stingl, G., Smolen, JS., Valenta, R., Lassmann, H., Kovar, H., Jäger, U., Kornek, G., Müller, M., Sörgel, F. (2016). Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. J Innate Immun. 8(2):111-20 (abstract)
 
van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, MT., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, LP., Polašek, O., Tanaka, T., Arking, DE., Ulivi, S., Trompet, S., Müller-Nurasyid, M., Smith, AV., Dörr, M., Kerr, KF., Magnani, JW., Del Greco M, F., Zhang, W., Nolte, IM., Silva, CT., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, GR., Adriaens, ME., Andersen, K., Barnett, P., Bis, JC., Bodmer, R., Buckley, BM., Campbell, H., Cannon, MV., Chakravarti, A., Chen, LY., Delitala, A., Devereux, RB., Doevendans, PA., Dominiczak, AF., Ferrucci, L., Ford, I., Gieger, C., Harris, TB., Haugen, E., Heinig, M., Hernandez, DG., Hillege, HL., Hirschhorn, JN., Hofman, A., Hubner, N., Hwang, SJ., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, IK., Kooner, JS., Kors, JA., Lakatta, EG., Lage, K., Launer, LJ., Levy, D., Lundby, A., Macfarlane, PW., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, AS., Nutile, T., Okin, PM., Olsen, JV., Oostra, BA., Penninger, JM., Pennacchio, LA., Pers, TH., Perz, S., Peters, A., Pinto, YM., Pfeufer, A., Pilia, MG., Pramstaller, PP., Prins, BP., Raitakari, OT., Raychaudhuri, S., Rice, KM., Rossin, EJ., Rotter, JI., Schafer, S., Schlessinger, D., Schmidt, CO., Sehmi, J., Silljé, HH., Sinagra, G., Sinner, MF., Slowikowski, K., Soliman, EZ., Spector, TD., Spiering, W., Stamatoyannopoulos, JA., Stolk, RP., Strauch, K., Tan, ST., Tarasov, KV., Trinh, B., Uitterlinden, AG., van den Boogaard, M., van Duijn, CM., van Gilst, WH., Viikari, JS., Visscher, PM., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, CX., Westra, HJ., Wijmenga, C., Wolffenbuttel, BH., Yang, J., Bezzina, CR., Munroe, PB., Snieder, H., Wright, AF., Rudan, I., Boyer, LA., Asselbergs, FW., van Veldhuisen, DJ., Stricker, BH., Psaty, BM., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, JF., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, JW., Kääb, S., Gudnason, V., Felix, SB., Heckbert, SR., de Boer, RA., Newton-Cheh, C., Hicks, AA., Chambers, JC., Jamshidi, Y., Visel, A., Christoffels, VM., Isaacs, A., Samani, NJ., de Bakker, PI. (2016). 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 68(13):1435-48 (abstract)
 
Wang, QP., Lin, YQ., Zhang, L., Wilson, YA., Oyston, LJ., Cotterell, J., Qi, Y., Khuong, TM., Bakhshi, N., Planchenault, Y., Browman, DT., Lau, MT., Cole, TA., Wong, AC., Simpson, SJ., Cole, AR., Penninger, JM., Herzog, H., Neely, GG. (2016). Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metab. 24(1):75-90 (abstract)
 
Wirnsberger, G., Zwolanek, F., Asaoka, T., Kozieradzki, I., Tortola, L., Wimmer, RA., Kavirayani, A., Fresser, F., Baier, G., Langdon, WY., Ikeda, F., Kuchler, K., Penninger, JM. (2016). Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 22(8):915-23 (abstract)
 
(2015)
 
Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24 (abstract)
 
Chen, Y., Di Grappa, MA., Molyneux, SD., McKee, TD., Waterhouse, P., Penninger, JM., Khokha, R. (2015). RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 7(317):317ra197 (abstract)
 
Dufresne, SS., Dumont, NA., Bouchard, P., Lavergne, É., Penninger, JM., Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. Am J Pathol. 185(4):920-6 (abstract)
 
Galluzzi, L., Bravo-San Pedro, JM., Vitale, I., Aaronson, SA., Abrams, JM., Adam, D., Alnemri, ES., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, EH., Bazan, NG., Bertrand, MJ., Bianchi, K., Blagosklonny, MV., Blomgren, K., Borner, C., Bredesen, DE., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, FK., Chandel, NS., Cheng, EH., Chipuk, JE., Cidlowski, JA., Ciechanover, A., Dawson, TM., Dawson, VL., De Laurenzi, V., De Maria, R., Debatin, KM., Di Daniele, N., Dixit, VM., Dynlacht, BD., El-Deiry, WS., Fimia, GM., Flavell, RA., Fulda, S., Garrido, C., Gougeon, ML., Green, DR., Gronemeyer, H., Hajnoczky, G., Hardwick, JM., Hengartner, MO., Ichijo, H., Joseph, B., Jost, PJ., Kaufmann, T., Kepp, O., Klionsky, DJ., Knight, RA., Kumar, S., Lemasters, JJ., Levine, B., Linkermann, A., Lipton, SA., Lockshin, RA., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, JC., Martin, SJ., Martinou, JC., Medema, JP., Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, JM., Peter, ME., Piacentini, M., Pinton, P., Prehn, JH., Puthalakath, H., Rabinovich, GA., Ravichandran, KS., Rizzuto, R., Rodrigues, CM., Rubinsztein, DC., Rudel, T., Shi, Y., Simon, HU., Stockwell, BR., Szabadkai, G., Tait, SW., Tang, HL., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, EF., Walczak, H., White, E., Wood, WG., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 22(1):58-73 (abstract)
 
Galluzzi, L., Pietrocola, F., Bravo-San Pedro, JM., Amaravadi, RK., Baehrecke, EH., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, DA., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, MC., Martin, SJ., Penninger, J., Piacentini, M., Rubinsztein, DC., Simon, HU., Simonsen, A., Thorburn, AM., Velasco, G., Ryan, KM., Kroemer, G. (2015). Autophagy in malignant transformation and cancer progression. EMBO J. 34(7):856-80 (abstract)
 
Grabner, B., Schramek, D., Mueller, KM., Moll, HP., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., Stiedl, P., Nivarthi, H., Bogner, E., Gruber, W., Mohr, T., Zwick, RH., Kenner, L., Poli, V., Aberger, F., Stoiber, D., Egger, G., Esterbauer, H., Zuber, J., Moriggl, R., Eferl, R., Győrffy, B., Penninger, JM., Popper, H., Casanova, E. (2015). Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 6:6285 (abstract)
 
Greenblatt, MB., Park, KH., Oh, H., Kim, JM., Shin, DY., Lee, JM., Lee, JW., Singh, A., Lee, KY., Hu, D., Xiao, C., Charles, JF., Penninger, JM., Lotinun, S., Baron, R., Ghosh, S., Shim, JH. (2015). CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 212(8):1283-301 (abstract)
 
Guerrini, MM., Okamoto, K., Komatsu, N., Sawa, S., Danks, L., Penninger, JM., Nakashima, T., Takayanagi, H. (2015). Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43(6):1174-85 (abstract)
 
Heier, C., Radner, FP., Moustafa, T., Schreiber, R., Grond, S., Eichmann, TO., Schweiger, M., Schmidt, A., Cerk, IK., Oberer, M., Theussl, HC., Wojciechowski, J., Penninger, JM., Zimmermann, R., Zechner, R. (2015). G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 290(43):26141-50 (abstract)
 
Joshi, PA., Waterhouse, PD., Kannan, N., Narala, S., Fang, H., Di Grappa, MA., Jackson, HW., Penninger, JM., Eaves, C., Khokha, R. (2015). RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5(1):31-44 (abstract)
 
Kondegowda, NG., Fenutria, R., Pollack, IR., Orthofer, M., Garcia-Ocaña, A., Penninger, JM., Vasavada, RC. (2015). Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metab. 22(1):77-85 (abstract)
 
Kulinski, TM., Casari, MR., Guenzl, PM., Wenzel, D., Andergassen, D., Hladik, A., Datlinger, P., Farlik, M., Theussl, HC., Penninger, JM., Knapp, S., Bock, C., Barlow, DP., Hudson, QJ. (2015). Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 402(2):291-305 (abstract)
 
Latremoliere, A., Latini, A., Andrews, N., Cronin, SJ., Fujita, M., Gorska, K., Hovius, R., Romero, C., Chuaiphichai, S., Painter, M., Miracca, G., Babaniyi, O., Remor, AP., Duong, K., Riva, P., Barrett, LB., Ferreirós, N., Naylor, A., Penninger, JM., Tegeder, I., Zhong, J., Blagg, J., Channon, KM., Johnsson, K., Costigan, M., Woolf, CJ. (2015). Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 86(6):1393-406 (abstract)
 
Lempradl, A., Pospisilik, JA., Penninger, JM. (2015). Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet. 16(11):665-81 (abstract)
 
Nagy, V., Cole, T., Van Campenhout, C., Khoung, TM., Leung, C., Vermeiren, S., Novatchkova, M., Wenzel, D., Cikes, D., Polyansky, AA., Kozieradzki, I., Meixner, A., Bellefroid, EJ., Neely, GG., Penninger, JM. (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle. 14(12):1799-808 (abstract)
 
Nagy, V., Penninger, JM. (2015). The RANKL-RANK Story. Gerontology. 61(6):534-42 (abstract)
 
Nakajima, K., Zhu, K., Sun, YH., Hegyi, B., Zeng, Q., Murphy, CJ., Small, JV., Chen-Izu, Y., Izumiya, Y., Penninger, JM., Zhao, M. (2015). KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 6:8532 (abstract)
 
Polizzotti, BD., Ganapathy, B., Walsh, S., Choudhury, S., Ammanamanchi, N., Bennett, DG., dos Remedios, CG., Haubner, BJ., Penninger, JM., Kühn, B. (2015). Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 7(281):281ra45 (abstract)
 
Schuetz T, Kuehn B, Penninger JM, Haubner BJ (2015). Direct comparison of ischemic- vs. cryoinjury in the neonatal mouse heart. Wiener Klinische Wochenschrift. (127):9-10
 
Sun, Y., Guo, F., Zou, Z., Li, C., Hong, X., Zhao, Y., Wang, C., Wang, H., Liu, H., Yang, P., Han, Z., Liu, K., Kuba, K., Song, B., Gao, J., Mo, Z., Li, D., Li, B., Li, Q., Zhong, N., Wang, C., Penninger, JM., Jiang, C. (2015). Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Part Fibre Toxicol. 12:4 (abstract)
 
Talbot, S., Abdulnour, RE., Burkett, PR., Lee, S., Cronin, SJ., Pascal, MA., Laedermann, C., Foster, SL., Tran, JV., Lai, N., Chiu, IM., Ghasemlou, N., DiBiase, M., Roberson, D., Von Hehn, C., Agac, B., Haworth, O., Seki, H., Penninger, JM., Kuchroo, VK., Bean, BP., Levy, BD., Woolf, CJ. (2015). Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 87(2):341-54 (abstract)
 
Tsvetkov, P., Mendillo, ML., Zhao, J., Carette, JE., Merrill, PH., Cikes, D., Varadarajan, M., van Diemen, FR., Penninger, JM., Goldberg, AL., Brummelkamp, TR., Santagata, S., Lindquist, S. (2015). Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4 (abstract)
 
Weitzer, S., Hanada, T., Penninger, JM., Martinez, J. (2015). CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders. Wiley Interdiscip Rev RNA. 6(1):47-63 (abstract)
 
(2014)
 
Boztug, K., Järvinen, PM., Salzer, E., Racek, T., Mönch, S., Garncarz, W., Gertz, EM., Schäffer, AA., Antonopoulos, A., Haslam, SM., Schieck, L., Puchałka, J., Diestelhorst, J., Appaswamy, G., Lescoeur, B., Giambruno, R., Bigenzahn, JW., Elling, U., Pfeifer, D., Conde, CD., Albert, MH., Welte, K., Brandes, G., Sherkat, R., van der Werff Ten Bosch, J., Rezaei, N., Etzioni, A., Bellanné-Chantelot, C., Superti-Furga, G., Penninger, JM., Bennett, KL., von Blume, J., Dell, A., Donadieu, J., Klein, C. (2014). JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 46(9):1021-7 (abstract)
 
Elling, U., Penninger, JM. (2014). Genome wide functional genetics in haploid cells. FEBS Lett. 588(15):2415-21 (abstract)
 
Huang, F., Guo, J., Zou, Z., Liu, J., Cao, B., Zhang, S., Li, H., Wang, W., Sheng, M., Liu, S., Pan, J., Bao, C., Zeng, M., Xiao, H., Qian, G., Hu, X., Chen, Y., Chen, Y., Zhao, Y., Liu, Q., Zhou, H., Zhu, J., Gao, H., Yang, S., Liu, X., Zheng, S., Yang, J., Diao, H., Cao, H., Wu, Y., Zhao, M., Tan, S., Guo, D., Zhao, X., Ye, Y., Wu, W., Xu, Y., Penninger, JM., Li, D., Gao, GF., Jiang, C., Li, L. (2014). Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 5:3595 (abstract)
 
Itoh, T., Horiuchi, M., Ikeda, RH., Xu, J., Bannerman, P., Pleasure, D., Penninger, JM., Tournier, C., Itoh, A. (2014). ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 34(32):10729-42 (abstract)
 
Karaca, E., Weitzer, S., Pehlivan, D., Shiraishi, H., Gogakos, T., Hanada, T., Jhangiani, SN., Wiszniewski, W., Withers, M., Campbell, IM., Erdin, S., Isikay, S., Franco, LM., Gonzaga-Jauregui, C., Gambin, T., Gelowani, V., Hunter, JV., Yesil, G., Koparir, E., Yilmaz, S., Brown, M., Briskin, D., Hafner, M., Morozov, P., Farazi, TA., Bernreuther, C., Glatzel, M., Trattnig, S., Friske, J., Kronnerwetter, C., Bainbridge, MN., Gezdirici, A., Seven, M., Muzny, DM., Boerwinkle, E., Ozen, M., Clausen, T., Tuschl, T., Yuksel, A., Hess, A., Gibbs, RA., Martinez, J., Penninger, JM., Lupski, JR. (2014). Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157(3):636-50 (abstract)
 
Kotsinas, A., Papanagnou, P., Galanos, P., Schramek, D., Townsend, P., Penninger, JM., Bartek, J., Gorgoulis, VG. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle. 13(8):1227-36 (abstract)
 
Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, AM., Langdon, WY., Ikeda, F., Fededa, JP., Cronin, SJ., Nitsch, R., Schultz-Fademrecht, C., Eickhoff, J., Menninger, S., Unger, A., Torka, R., Gruber, T., Hinterleitner, R., Baier, G., Wolf, D., Ullrich, A., Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12 (abstract)
 
Qiao, G., Ying, H., Zhao, Y., Liang, Y., Guo, H., Shen, H., Li, Z., Solway, J., Tao, E., Chiang, YJ., Lipkowitz, S., Penninger, JM., Langdon, WY., Zhang, J. (2014). E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep. 6(4):709-23 (abstract)
 
Rao, S., Tortola, L., Perlot, T., Wirnsberger, G., Novatchkova, M., Nitsch, R., Sykacek, P., Frank, L., Schramek, D., Komnenovic, V., Sigl, V., Aumayr, K., Schmauss, G., Fellner, N., Handschuh, S., Glösmann, M., Pasierbek, P., Schlederer, M., Resch, GP., Ma, Y., Yang, H., Popper, H., Kenner, L., Kroemer, G., Penninger, JM. (2014). A dual role for autophagy in a murine model of lung cancer. Nat Commun. 5:3056 (abstract)
 
Rao, S., Yang, H., Penninger, JM., Kroemer, G. (2014). Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10(3):529-31 (abstract)
 
Rotblat, B., Southwell, AL., Ehrnhoefer, DE., Skotte, NH., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, SP., Barokas, A., Deng, Y., Tang, T., Mathers, J., Cetinbas, N., Daugaard, M., Kwok, B., Li, L., Carnie, CJ., Fink, D., Nitsch, R., Galpin, JD., Ahern, CA., Melino, G., Penninger, JM., Hayden, MR., Sorensen, PH. (2014). HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A. 111(8):3032-7 (abstract)
 
Sigl, V., Penninger, JM. (2014). RANKL/RANK - from bone physiology to breast cancer. Cytokine Growth Factor Rev. 25(2):205-14 (abstract)
 
Wang, W., Patel, VB., Parajuli, N., Fan, D., Basu, R., Wang, Z., Ramprasath, T., Kassiri, Z., Penninger, JM., Oudit, GY. (2014). Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. J Mol Med (Berl). 92(8):847-58 (abstract)
 
Wenzel, D., Bayerl, J., Nyström, A., Bruckner-Tuderman, L., Meixner, A., Penninger, JM. (2014). Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Sci Transl Med. 6(264):264ra165 (abstract)
 
Wirnsberger, G., Zwolanek, F., Stadlmann, J., Tortola, L., Liu, SW., Perlot, T., Järvinen, P., Dürnberger, G., Kozieradzki, I., Sarao, R., De Martino, A., Boztug, K., Mechtler, K., Kuchler, K., Klein, C., Elling, U., Penninger, JM. (2014). Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 46(9):1028-33 (abstract)
 
Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., Chen, W., Zhen, W., Cai, M., Penninger, JM., Jiang, C., Wang, X. (2014). Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 4:7027 (abstract)
 
Zhang, L., Chen, X., Sharma, P., Moon, M., Sheftel, AD., Dawood, F., Nghiem, MP., Wu, J., Li, RK., Gramolini, AO., Sorensen, PH., Penninger, JM., Brumell, JH., Liu, PP. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 5:3430 (abstract)
 
Zou, Z., Yan, Y., Shu, Y., Gao, R., Sun, Y., Li, X., Ju, X., Liang, Z., Liu, Q., Zhao, Y., Guo, F., Bai, T., Han, Z., Zhu, J., Zhou, H., Huang, F., Li, C., Lu, H., Li, N., Li, D., Jin, N., Penninger, JM., Jiang, C. (2014). Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 5:3594 (abstract)
 
(2013)
 
Badger-Brown, KM., Gillis, LC., Bailey, ML., Penninger, JM., Barber, DL. (2013). CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 27(5):1146-54 (abstract)
 
Daugaard, M., Nitsch, R., Razaghi, B., McDonald, L., Jarrar, A., Torrino, S., Castillo-Lluva, S., Rotblat, B., Li, L., Malliri, A., Lemichez, E., Mettouchi, A., Berman, JN., Penninger, JM., Sorensen, PH. (2013). Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 4:2180 (abstract)
 
Fielding, RA., Gunstad, J., Gustafson, DR., Heymsfield, SB., Kral, JG., Launer, LJ., Penninger, J., Phillips, DI., Scarmeas, N. (2013). The paradox of overnutrition in aging and cognition. Ann N Y Acad Sci. 1287:31-43 (abstract)
 
Furuya, Y., Inagaki, A., Khan, M., Mori, K., Penninger, JM., Nakamura, M., Udagawa, N., Aoki, K., Ohya, K., Uchida, K., Yasuda, H. (2013). Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem. 288(8):5562-71 (abstract)
 
Hanada, T., Weitzer, S., Mair, B., Bernreuther, C., Wainger, BJ., Ichida, J., Hanada, R., Orthofer, M., Cronin, SJ., Komnenovic, V., Minis, A., Sato, F., Mimata, H., Yoshimura, A., Tamir, I., Rainer, J., Kofler, R., Yaron, A., Eggan, KC., Woolf, CJ., Glatzel, M., Herbst, R., Martinez, J., Penninger, JM. (2013). CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495(7442):474-80 (abstract)
 
Haschke, M., Schuster, M., Poglitsch, M., Loibner, H., Salzberg, M., Bruggisser, M., Penninger, J., Krähenbühl, S. (2013). Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet. 52(9):783-92 (abstract)
 
Ichikawa, A., Kuba, K., Morita, M., Chida, S., Tezuka, H., Hara, H., Sasaki, T., Ohteki, T., Ranieri, VM., dos Santos, CC., Kawaoka, Y., Akira, S., Luster, AD., Lu, B., Penninger, JM., Uhlig, S., Slutsky, AS., Imai, Y. (2013). CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 187(1):65-77 (abstract)
 
Jux, B., Staratschek-Jox, A., Penninger, JM., Schultze, JL., Kolanus, W. (2013). Vav1 regulates MHCII expression in murine resting and activated B cells. Int Immunol. 25(5):307-17 (abstract)
 
Kiechl, S., Wittmann, J., Giaccari, A., Knoflach, M., Willeit, P., Bozec, A., Moschen, AR., Muscogiuri, G., Sorice, GP., Kireva, T., Summerer, M., Wirtz, S., Luther, J., Mielenz, D., Billmeier, U., Egger, G., Mayr, A., Oberhollenzer, F., Kronenberg, F., Orthofer, M., Penninger, JM., Meigs, JB., Bonora, E., Tilg, H., Willeit, J., Schett, G. (2013). Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 19(3):358-63 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2013). Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circ J. 77(2):301-8 (abstract)
 
Lancaster, MA., Renner, M., Martin, CA., Wenzel, D., Bicknell, LS., Hurles, ME., Homfray, T., Penninger, JM., Jackson, AP., Knoblich, JA. (2013). Cerebral organoids model human brain development and microcephaly. Nature. 501(7467):373-9 (abstract)
 
Lee, HJ., Gallego-Ortega, D., Ledger, A., Schramek, D., Joshi, P., Szwarc, MM., Cho, C., Lydon, JP., Khokha, R., Penninger, JM., Ormandy, CJ. (2013). Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development. 140(7):1397-401 (abstract)
 
Lo, J., Patel, VB., Wang, Z., Levasseur, J., Kaufman, S., Penninger, JM., Oudit, GY. (2013). Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 98(1):109-22 (abstract)
 
Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanebe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadowaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, JM., Arita, M., Imai, Y. (2013). The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 153(1):112-25 (abstract)
 
Offord, EA., Karagounis, LG., Vidal, K., Fielding, R., Meydani, S., Penninger, JM. (2013). Nutrition and the biology of human ageing: bone health and osteoporosis / sarcopenia / immune deficiency. J Nutr Health Aging. 17(8):712-6 (abstract)
 
Paul, DS., Albers, CA., Rendon, A., Voss, K., Stephens, J., van der Harst, P., Chambers, JC., Soranzo, N., Ouwehand, WH., Deloukas, P. (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res. 23(7):1130-41 (abstract)
 
Perlot, T., Penninger, JM. (2013). ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 15(13):866-73 (abstract)
 
Raith, M., Valencia, RG., Fischer, I., Orthofer, M., Penninger, JM., Spuler, S., Rezniczek, GA., Wiche, G. (2013). Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skelet Muscle. 3(1):14 (abstract)
 
Sato, T., Suzuki, T., Watanabe, H., Kadowaki, A., Fukamizu, A., Liu, PP., Kimura, A., Ito, H., Penninger, JM., Imai, Y., Kuba, K. (2013). Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest. 123(12):5203-11 (abstract)
 
Song, B., Jin, H., Yu, X., Zhang, Z., Yu, H., Ye, J., Xu, Y., Zhou, T., Oudit, GY., Ye, JY., Chen, C., Gao, P., Zhu, D., Penninger, JM., Zhong, JC. (2013). Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept. 185:44-51 (abstract)
 
Wallner, S., Lutz-Nicoladoni, C., Tripp, CH., Gastl, G., Baier, G., Penninger, JM., Stoitzner, P., Wolf, D. (2013). The role of the e3 ligase cbl-B in murine dendritic cells. PLoS One. 8(6):e65178 (abstract)
 
Wang, W., McKinnie, SM., Patel, VB., Haddad, G., Wang, Z., Zhabyeyev, P., Das, SK., Basu, R., McLean, B., Kandalam, V., Penninger, JM., Kassiri, Z., Vederas, JC., Murray, AG., Oudit, GY. (2013). Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2(4):e000249 (abstract)
 
Wang, W., Yang, P., Zhong, Y., Zhao, Z., Xing, L., Zhao, Y., Zou, Z., Zhang, Y., Li, C., Li, T., Wang, C., Wang, Z., Yu, X., Cao, B., Gao, X., Penninger, JM., Wang, X., Jiang, C. (2013). Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Res. 23(4):577-80 (abstract)
 
Wöhrle, FU., Halbach, S., Aumann, K., Schwemmers, S., Braun, S., Auberger, P., Schramek, D., Penninger, JM., Laßmann, S., Werner, M., Waller, CF., Pahl, HL., Zeiser, R., Daly, RJ., Brummer, T. (2013). Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 27(1):118-29 (abstract)
 
Zhang, ZZ., Shang, QH., Jin, HY., Song, B., Oudit, GY., Lu, L., Zhou, T., Xu, YL., Gao, PJ., Zhu, DL., Penninger, JM., Zhong, JC. (2013). Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 11:229 (abstract)
 
(2012)
 
Arai, A., Mizoguchi, T., Harada, S., Kobayashi, Y., Nakamichi, Y., Yasuda, H., Penninger, JM., Yamada, K., Udagawa, N., Takahashi, N. (2012). Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment. J Cell Sci. 125(Pt 12):2910-7 (abstract)
 
Attané, C., Foussal, C., Le Gonidec, S., Benani, A., Daviaud, D., Wanecq, E., Guzmán-Ruiz, R., Dray, C., Bezaire, V., Rancoule, C., Kuba, K., Ruiz-Gayo, M., Levade, T., Penninger, J., Burcelin, R., Pénicaud, L., Valet, P., Castan-Laurell, I. (2012). Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 61(2):310-20 (abstract)
 
Desanti, GE., Cowan, JE., Baik, S., Parnell, SM., White, AJ., Penninger, JM., Lane, PJ., Jenkinson, EJ., Jenkinson, WE., Anderson, G. (2012). Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. J Immunol. 189(12):5519-26 (abstract)
 
Douni, E., Rinotas, V., Makrinou, E., Zwerina, J., Penninger, JM., Eliopoulos, E., Schett, G., Kollias, G. (2012). A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 21(4):784-98 (abstract)
 
Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Yang, L., Lipkowitz, S., Penninger, JM., Langdon, WY., Zhang, J. (2012). E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep. 1(5):472-82 (abstract)
 
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B., Camargo, SM., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., Rosenstiel, P., Penninger, JM. (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81 (abstract)
 
Haubner, BJ., Adamowicz-Brice, M., Khadayate, S., Tiefenthaler, V., Metzler, B., Aitman, T., Penninger, JM. (2012). Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY). 4(12):966-77 (abstract)
 
Hinterleitner, R., Gruber, T., Pfeifhofer-Obermair, C., Lutz-Nicoladoni, C., Tzankov, A., Schuster, M., Penninger, JM., Loibner, H., Lametschwandtner, G., Wolf, D., Baier, G. (2012). Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. PLoS One. 7(9):e44295 (abstract)
 
Jin, HY., Song, B., Oudit, GY., Davidge, ST., Yu, HM., Jiang, YY., Gao, PJ., Zhu, DL., Ning, G., Kassiri, Z., Penninger, JM., Zhong, JC. (2012). ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One. 7(6):e38502 (abstract)
 
Kleinsasser, A., Pircher, I., Treml, B., Schwienbacher, M., Schuster, M., Janzek, E., Loibner, H., Penninger, JM., Loeckinger, A. (2012). Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia. Wilderness Environ Med. 23(1):24-30 (abstract)
 
Laimer, D., Dolznig, H., Kollmann, K., Vesely, PW., Schlederer, M., Merkel, O., Schiefer, AI., Hassler, MR., Heider, S., Amenitsch, L., Thallinger, C., Staber, PB., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Turner, SD., Pileri, S., Piccaluga, PP., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Höfler, G., Piva, R., Medico, E., Ruggeri, BA., Cheng, M., Eferl, R., Egger, G., Penninger, JM., Jaeger, U., Moriggl, R., Inghirami, G., Kenner, L. (2012). PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med. 18(11):1699-704 (abstract)
 
Liu, Z., Huang, XR., Chen, HY., Penninger, JM., Lan, HY. (2012). Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy. Lab Invest. 92(5):650-61 (abstract)
 
Lutz-Nicoladoni, C., Wallner, S., Stoitzner, P., Pircher, M., Gruber, T., Wolf, AM., Gastl, G., Penninger, JM., Baier, G., Wolf, D. (2012). Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunol Cell Biol. 90(1):130-4 (abstract)
 
Musteanu, M., Blaas, L., Zenz, R., Svinka, J., Hoffmann, T., Grabner, B., Schramek, D., Kantner, HP., Müller, M., Kolbe, T., Rülicke, T., Moriggl, R., Kenner, L., Stoiber, D., Penninger, JM., Popper, H., Casanova, E., Eferl, R. (2012). A mouse model to identify cooperating signaling pathways in cancer. Nat Methods. 9(9):897-900 (abstract)
 
Nakamichi, Y., Mizoguchi, T., Arai, A., Kobayashi, Y., Sato, M., Penninger, JM., Yasuda, H., Kato, S., DeLuca, HF., Suda, T., Udagawa, N., Takahashi, N. (2012). Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice. Proc Natl Acad Sci U S A. 109(25):10006-11 (abstract)
 
Neely, GG., Rao, S., Costigan, M., Mair, N., Racz, I., Milinkeviciute, G., Meixner, A., Nayanala, S., Griffin, RS., Belfer, I., Dai, F., Smith, S., Diatchenko, L., Marengo, S., Haubner, BJ., Novatchkova, M., Gibson, D., Maixner, W., Pospisilik, JA., Hirsch, E., Whishaw, IQ., Zimmer, A., Gupta, V., Sasaki, J., Kanaho, Y., Sasaki, T., Kress, M., Woolf, CJ., Penninger, JM. (2012). Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 8(12):e1003071 (abstract)
 
Peña Silva, RA., Chu, Y., Miller, JD., Mitchell, IJ., Penninger, JM., Faraci, FM., Heistad, DD. (2012). Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke. 43(12):3358-63 (abstract)
 
Perlot, T., Penninger, JM. (2012). Development and function of murine B cells lacking RANK. J Immunol. 188(3):1201-5 (abstract)
 
Qi, Y., Tian, X., Liu, J., Han, Y., Graham, AM., Simon, MC., Penninger, JM., Carmeliet, P., Li, S. (2012). Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 198(1):103-14 (abstract)
 
Rey-Parra, GJ., Vadivel, A., Coltan, L., Hall, A., Eaton, F., Schuster, M., Loibner, H., Penninger, JM., Kassiri, Z., Oudit, GY., Thébaud, B. (2012). Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. J Mol Med (Berl). 90(6):637-47 (abstract)
 
Roberts, NA., White, AJ., Jenkinson, WE., Turchinovich, G., Nakamura, K., Withers, DR., McConnell, FM., Desanti, GE., Benezech, C., Parnell, SM., Cunningham, AF., Paolino, M., Penninger, JM., Simon, AK., Nitta, T., Ohigashi, I., Takahama, Y., Caamano, JH., Hayday, AC., Lane, PJ., Jenkinson, EJ., Anderson, G. (2012). Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity. 36(3):427-37 (abstract)
 
Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., Shen, S., Mariño, G., Criollo, A., Boilève, A., Job, B., Ladoire, S., Ghiringhelli, F., Sistigu, A., Yamazaki, T., Rello-Varona, S., Locher, C., Poirier-Colame, V., Talbot, M., Valent, A., Berardinelli, F., Antoccia, A., Ciccosanti, F., Fimia, GM., Piacentini, M., Fueyo, A., Messina, NL., Li, M., Chan, CJ., Sigl, V., Pourcher, G., Ruckenstuhl, C., Carmona-Gutierrez, D., Lazar, V., Penninger, JM., Madeo, F., López-Otín, C., Smyth, MJ., Zitvogel, L., Castedo, M., Kroemer, G. (2012). An immunosurveillance mechanism controls cancer cell ploidy. Science. 337(6102):1678-84 (abstract)
 
Singer, D., Camargo, SM., Ramadan, T., Schäfer, M., Mariotta, L., Herzog, B., Huggel, K., Wolfer, D., Werner, S., Penninger, JM., Verrey, F. (2012). Defective intestinal amino acid absorption in Ace2 null mice. Am J Physiol Gastrointest Liver Physiol. 303(6):G686-95 (abstract)
 
Teperino, R., Amann, S., Bayer, M., McGee, SL., Loipetzberger, A., Connor, T., Jaeger, C., Kammerer, B., Winter, L., Wiche, G., Dalgaard, K., Selvaraj, M., Gaster, M., Lee-Young, RS., Febbraio, MA., Knauf, C., Cani, PD., Aberger, F., Penninger, JM., Pospisilik, JA., Esterbauer, H. (2012). Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell. 151(2):414-26 (abstract)
 
van der Harst, P., Zhang, W., Mateo Leach, I., Rendon, A., Verweij, N., Sehmi, J., Paul, DS., Elling, U., Allayee, H., Li, X., Radhakrishnan, A., Tan, ST., Voss, K., Weichenberger, CX., Albers, CA., Al-Hussani, A., Asselbergs, FW., Ciullo, M., Danjou, F., Dina, C., Esko, T., Evans, DM., Franke, L., Gögele, M., Hartiala, J., Hersch, M., Holm, H., Hottenga, JJ., Kanoni, S., Kleber, ME., Lagou, V., Langenberg, C., Lopez, LM., Lyytikäinen, LP., Melander, O., Murgia, F., Nolte, IM., O'Reilly, PF., Padmanabhan, S., Parsa, A., Pirastu, N., Porcu, E., Portas, L., Prokopenko, I., Ried, JS., Shin, SY., Tang, CS., Teumer, A., Traglia, M., Ulivi, S., Westra, HJ., Yang, J., Zhao, JH., Anni, F., Abdellaoui, A., Attwood, A., Balkau, B., Bandinelli, S., Bastardot, F., Benyamin, B., Boehm, BO., Cookson, WO., Das, D., de Bakker, PI., de Boer, RA., de Geus, EJ., de Moor, MH., Dimitriou, M., Domingues, FS., Döring, A., Engström, G., Eyjolfsson, GI., Ferrucci, L., Fischer, K., Galanello, R., Garner, SF., Genser, B., Gibson, QD., Girotto, G., Gudbjartsson, DF., Harris, SE., Hartikainen, AL., Hastie, CE., Hedblad, B., Illig, T., Jolley, J., Kähönen, M., Kema, IP., Kemp, JP., Liang, L., Lloyd-Jones, H., Loos, RJ., Meacham, S., Medland, SE., Meisinger, C., Memari, Y., Mihailov, E., Miller, K., Moffatt, MF., Nauck, M., Novatchkova, M., Nutile, T., Olafsson, I., Onundarson, PT., Parracciani, D., Penninx, BW., Perseu, L., Piga, A., Pistis, G., Pouta, A., Puc, U., Raitakari, O., Ring, SM., Robino, A., Ruggiero, D., Ruokonen, A., Saint-Pierre, A., Sala, C., Salumets, A., Sambrook, J., Schepers, H., Schmidt, CO., Silljé, HH., Sladek, R., Smit, JH., Starr, JM., Stephens, J., Sulem, P., Tanaka, T., Thorsteinsdottir, U., Tragante, V., van Gilst, WH., van Pelt, LJ., van Veldhuisen, DJ., Völker, U., Whitfield, JB., Willemsen, G., Winkelmann, BR., Wirnsberger, G., Algra, A., Cucca, F., d'Adamo, AP., Danesh, J., Deary, IJ., Dominiczak, AF., Elliott, P., Fortina, P., Froguel, P., Gasparini, P., Greinacher, A., Hazen, SL., Jarvelin, MR., Khaw, KT., Lehtimäki, T., Maerz, W., Martin, NG., Metspalu, A., Mitchell, BD., Montgomery, GW., Moore, C., Navis, G., Pirastu, M., Pramstaller, PP., Ramirez-Solis, R., Schadt, E., Scott, J., Shuldiner, AR., Smith, GD., Smith, JG., Snieder, H., Sorice, R., Spector, TD., Stefansson, K., Stumvoll, M., Tang, WH., Toniolo, D., Tönjes, A., Visscher, PM., Vollenweider, P., Wareham, NJ., Wolffenbuttel, BH., Boomsma, DI., Beckmann, JS., Dedoussis, GV., Deloukas, P., Ferreira, MA., Sanna, S., Uda, M., Hicks, AA., Penninger, JM., Gieger, C., Kooner, JS., Ouwehand, WH., Soranzo, N., Chambers, JC. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature. 492(7429):369-75 (abstract)
 
Winchester, CL., Ohzeki, H., Vouyiouklis, DA., Thompson, R., Penninger, JM., Yamagami, K., Norrie, JD., Hunter, R., Pratt, JA., Morris, BJ. (2012). Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Hum Mol Genet. 21(22):4910-21 (abstract)
 
Xiol, J., Cora, E., Koglgruber, R., Chuma, S., Subramanian, S., Hosokawa, M., Reuter, M., Yang, Z., Berninger, P., Palencia, A., Benes, V., Penninger, J., Sachidanandam, R., Pillai, RS. (2012). A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 47(6):970-9 (abstract)
 
(2011)
 
Bodiga, S., Zhong, JC., Wang, W., Basu, R., Lo, J., Liu, GC., Guo, D., Holland, SM., Scholey, JW., Penninger, JM., Kassiri, Z., Oudit, GY. (2011). Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res. 91(1):151-61 (abstract)
 
Duheron, V., Hess, E., Duval, M., Decossas, M., Castaneda, B., Klöpper, JE., Amoasii, L., Barbaroux, JB., Williams, IR., Yagita, H., Penninger, J., Choi, Y., Lézot, F., Groves, R., Paus, R., Mueller, CG. (2011). Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A. 108(13):5342-7 (abstract)
 
Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, SP., Vanhaelen, Q., Shukalyuk, AI., Schmauss, G., Schramek, D., Schnuetgen, F., von Melchner, H., Ecker, JR., Stanford, WL., Zuber, J., Stark, A., Penninger, JM. (2011). Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74 (abstract)
 
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, AH., Labrune, Y., Lopez, LM., Mägi, R., Meacham, S., Okada, Y., Pirastu, N., Sorice, R., Teumer, A., Voss, K., Zhang, W., Ramirez-Solis, R., Bis, JC., Ellinghaus, D., Gögele, M., Hottenga, JJ., Langenberg, C., Kovacs, P., O'Reilly, PF., Shin, SY., Esko, T., Hartiala, J., Kanoni, S., Murgia, F., Parsa, A., Stephens, J., van der Harst, P., Ellen van der Schoot, C., Allayee, H., Attwood, A., Balkau, B., Bastardot, F., Basu, S., Baumeister, SE., Biino, G., Bomba, L., Bonnefond, A., Cambien, F., Chambers, JC., Cucca, F., D'Adamo, P., Davies, G., de Boer, RA., de Geus, EJ., Döring, A., Elliott, P., Erdmann, J., Evans, DM., Falchi, M., Feng, W., Folsom, AR., Frazer, IH., Gibson, QD., Glazer, NL., Hammond, C., Hartikainen, AL., Heckbert, SR., Hengstenberg, C., Hersch, M., Illig, T., Loos, RJ., Jolley, J., Khaw, KT., Kühnel, B., Kyrtsonis, MC., Lagou, V., Lloyd-Jones, H., Lumley, T., Mangino, M., Maschio, A., Mateo Leach, I., McKnight, B., Memari, Y., Mitchell, BD., Montgomery, GW., Nakamura, Y., Nauck, M., Navis, G., Nöthlings, U., Nolte, IM., Porteous, DJ., Pouta, A., Pramstaller, PP., Pullat, J., Ring, SM., Rotter, JI., Ruggiero, D., Ruokonen, A., Sala, C., Samani, NJ., Sambrook, J., Schlessinger, D., Schreiber, S., Schunkert, H., Scott, J., Smith, NL., Snieder, H., Starr, JM., Stumvoll, M., Takahashi, A., Tang, WH., Taylor, K., Tenesa, A., Lay Thein, S., Tönjes, A., Uda, M., Ulivi, S., van Veldhuisen, DJ., Visscher, PM., Völker, U., Wichmann, HE., Wiggins, KL., Willemsen, G., Yang, TP., Hua Zhao, J., Zitting, P., Bradley, JR., Dedoussis, GV., Gasparini, P., Hazen, SL., Metspalu, A., Pirastu, M., Shuldiner, AR., Joost van Pelt, L., Zwaginga, JJ., Boomsma, DI., Deary, IJ., Franke, A., Froguel, P., Ganesh, SK., Jarvelin, MR., Martin, NG., Meisinger, C., Psaty, BM., Spector, TD., Wareham, NJ., Akkerman, JW., Ciullo, M., Deloukas, P., Greinacher, A., Jupe, S., Kamatani, N., Khadake, J., Kooner, JS., Penninger, J., Prokopenko, I., Stemple, D., Toniolo, D., Wernisch, L., Sanna, S., Hicks, AA., Rendon, A., Ferreira, MA., Ouwehand, WH., Soranzo, N. (2011). New gene functions in megakaryopoiesis and platelet formation. Nature. 480(7376):201-8 (abstract)
 
Hanada, R., Hanada, T., Sigl, V., Schramek, D., Penninger, JM. (2011). RANKL/RANK-beyond bones. J Mol Med (Berl). 89(7):647-56 (abstract)
 
Hanada, R., Penninger, JM. (2011). [Central regulation of body temperature by RANKL/RANK pathway]. Clin Calcium. 21(8):1201-8 (abstract)
 
Jin, R., Song, Z., Yu, S., Piazza, A., Nanda, A., Penninger, JM., Granger, DN., Li, G. (2011). Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Stroke. 42(7):2033-44 (abstract)
 
Kaminski, S., Hermann-Kleiter, N., Meisel, M., Thuille, N., Cronin, S., Hara, H., Fresser, F., Penninger, JM., Baier, G. (2011). Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun. 37(3):198-208 (abstract)
 
Koletar, MM., Cheng, HY., Penninger, JM., Ralph, MR. (2011). Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 28(7):553-62 (abstract)
 
Kornfeld, JW., Isaacs, A., Vitart, V., Pospisilik, JA., Meitinger, T., Gyllensten, U., Wilson, JF., Rudan, I., Campbell, H., Penninger, JM., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, PP., Hicks, AA. (2011). Variants in STAT5B associate with serum TC and LDL-C levels. J Clin Endocrinol Metab. 96(9):E1496-501 (abstract)
 
Lee, AW., Mao, Y., Penninger, JM., Yu, S. (2011). Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development. Mol Cell Biol. 31(22):4563-81 (abstract)
 
Leibbrandt, A., Penninger, JM. (2011). TNF conference 2009: beyond bones - RANKL/RANK in the immune system. Adv Exp Med Biol. 691:5-22 (abstract)
 
Meng, X., Arocena, M., Penninger, J., Gage, FH., Zhao, M., Song, B. (2011). PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 227(1):210-7 (abstract)
 
Miyamoto, K., Yoshida, S., Kawasumi, M., Hashimoto, K., Kimura, T., Sato, Y., Kobayashi, T., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Hao, W., Morioka, H., Chiba, K., Kobayashi, T., Yasuda, H., Penninger, JM., Toyama, Y., Suda, T., Miyamoto, T. (2011). Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med. 208(11):2175-81 (abstract)
 
Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, JM., Inoue, J., Akiyama, T., Matsumoto, M. (2011). Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 186(9):5047-57 (abstract)
 
Muto, A., Mizoguchi, T., Udagawa, N., Ito, S., Kawahara, I., Abiko, Y., Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y., Penninger, JM., Noguchi, T., Takahashi, N. (2011). Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res. 26(12):2978-90 (abstract)
 
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-Hora, M., Feng, JQ., Bonewald, LF., Kodama, T., Wutz, A., Wagner, EF., Penninger, JM., Takayanagi, H. (2011). Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 17(10):1231-4 (abstract)
 
Neely, GG., Keene, AC., Duchek, P., Chang, EC., Wang, QP., Aksoy, YA., Rosenzweig, M., Costigan, M., Woolf, CJ., Garrity, PA., Penninger, JM. (2011). TrpA1 regulates thermal nociception in Drosophila. PLoS One. 6(8):e24343 (abstract)
 
Oh, SY., Park, JU., Zheng, T., Kim, YK., Wu, F., Cho, SH., Barber, D., Penninger, J., Zhu, Z. (2011). Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy. 41(3):434-42 (abstract)
 
Oudit, GY., Penninger, JM. (2011). Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 8(3):176-83 (abstract)
 
Paolino, M., Thien, CB., Gruber, T., Hinterleitner, R., Baier, G., Langdon, WY., Penninger, JM. (2011). Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol. 186(4):2138-47 (abstract)
 
Schramek, D., Kotsinas, A., Meixner, A., Wada, T., Elling, U., Pospisilik, JA., Neely, GG., Zwick, RH., Sigl, V., Forni, G., Serrano, M., Gorgoulis, VG., Penninger, JM. (2011). The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 43(3):212-9 (abstract)
 
Schramek, D., Sigl, V., Penninger, JM. (2011). RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 22(5):188-94 (abstract)
 
Taschler, U., Radner, FP., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Koefeler, HC., Wojciechowski, J., Theussl, C., Penninger, JM., Lass, A., Haemmerle, G., Zechner, R., Zimmermann, R. (2011). Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem. 286(20):17467-77 (abstract)
 
Yamasaki, T., Kawasaki, H., Arakawa, S., Shimizu, K., Shimizu, S., Reiner, O., Okano, H., Nishina, S., Azuma, N., Penninger, JM., Katada, T., Nishina, H. (2011). Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 31(46):16872-83 (abstract)
 
Zhong, JC., Ye, JY., Jin, HY., Yu, X., Yu, HM., Zhu, DL., Gao, PJ., Huang, DY., Shuster, M., Loibner, H., Guo, JM., Yu, XY., Xiao, BX., Gong, ZH., Penninger, JM., Oudit, GY. (2011). Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept. 166(1-3):90-7 (abstract)
 
Zhong, J., Guo, D., Chen, CB., Wang, W., Schuster, M., Loibner, H., Penninger, JM., Scholey, JW., Kassiri, Z., Oudit, GY. (2011). Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57(2):314-22 (abstract)
 
(2010)
 
Awad, AE., Kandalam, V., Chakrabarti, S., Wang, X., Penninger, JM., Davidge, ST., Oudit, GY., Kassiri, Z. (2010). Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol. 298(3):C679-92 (abstract)
 
Blaas, L., Kornfeld, JW., Schramek, D., Musteanu, M., Zollner, G., Gumhold, J., van Zijl, F., Schneller, D., Esterbauer, H., Egger, G., Mair, M., Kenner, L., Mikulits, W., Eferl, R., Moriggl, R., Penninger, J., Trauner, M., Casanova, E. (2010). Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology. 51(4):1319-26 (abstract)
 
Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, PC., Haslam, SM., Dell, A., Penninger, J., Erneux, C., Piette, J., Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. 24(4):821-32 (abstract)
 
del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, JS., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., Penninger, J., Eichmann, A. (2010). Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116(19):4025-33 (abstract)
 
Fleuren, ED., O'Toole, S., Millar, EK., McNeil, C., Lopez-Knowles, E., Boulghourjian, A., Croucher, DR., Schramek, D., Brummer, T., Penninger, JM., Sutherland, RL., Daly, RJ. (2010). Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer. 127(6):1486-92 (abstract)
 
Guo, D., Kassiri, Z., Basu, R., Chow, FL., Kandalam, V., Damilano, F., Liang, W., Izumo, S., Hirsch, E., Penninger, JM., Backx, PH., Oudit, GY. (2010). Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res. 107(10):1275-89 (abstract)
 
Hanada, R., Hanada, T., Penninger, JM. (2010). Physiology and pathophysiology of the RANKL/RANK system. Biol Chem. 391(12):1365-70 (abstract)
 
Haubner, BJ., Neely, GG., Voelkl, JG., Damilano, F., Kuba, K., Imai, Y., Komnenovic, V., Mayr, A., Pachinger, O., Hirsch, E., Penninger, JM., Metzler, B. (2010). PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS One. 5(2):e9350 (abstract)
 
Heindl-Erdmann, C., Axmann, R., Kreitz, S., Zwerina, J., Penninger, J., Schett, G., Brune, K., Hess, A. (2010). Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport. 21(1):29-33 (abstract)
 
Imai, Y., Kuba, K., Ohto-Nakanishi, T., Penninger, JM. (2010). Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3):405-10 (abstract)
 
Jin, R., Yu, S., Song, Z., Quillin, JW., Deasis, DP., Penninger, JM., Nanda, A., Granger, DN., Li, G. (2010). Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochem Biophys Res Commun. 399(3):458-64 (abstract)
 
Klaiber, M., Kruse, M., Völker, K., Schröter, J., Feil, R., Freichel, M., Gerling, A., Feil, S., Dietrich, A., Londoño, JE., Baba, HA., Abramowitz, J., Birnbaumer, L., Penninger, JM., Pongs, O., Kuhn, M. (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 105(5):583-95 (abstract)
 
Kuba, K., Imai, Y., Ohto-Nakanishi, T., Penninger, JM. (2010). Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 128(1):119-28 (abstract)
 
Leibbrandt, A., Penninger, JM. (2010). Novel functions of RANK(L) signaling in the immune system. Adv Exp Med Biol. 658:77-94 (abstract)
 
Meixner, A., Karreth, F., Kenner, L., Penninger, JM., Wagner, EF. (2010). Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 17(9):1409-19 (abstract)
 
Molyneux, SD., Di Grappa, MA., Beristain, AG., McKee, TD., Wai, DH., Paderova, J., Kashyap, M., Hu, P., Maiuri, T., Narala, SR., Stambolic, V., Squire, J., Penninger, J., Sanchez, O., Triche, TJ., Wood, GA., Kirschner, LS., Khokha, R. (2010). Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 120(9):3310-25 (abstract)
 
Neely, GG., Hess, A., Costigan, M., Keene, AC., Goulas, S., Langeslag, M., Griffin, RS., Belfer, I., Dai, F., Smith, SB., Diatchenko, L., Gupta, V., Xia, CP., Amann, S., Kreitz, S., Heindl-Erdmann, C., Wolz, S., Ly, CV., Arora, S., Sarangi, R., Dan, D., Novatchkova, M., Rosenzweig, M., Gibson, DG., Truong, D., Schramek, D., Zoranovic, T., Cronin, SJ., Angjeli, B., Brune, K., Dietzl, G., Maixner, W., Meixner, A., Thomas, W., Pospisilik, JA., Alenius, M., Kress, M., Subramaniam, S., Garrity, PA., Bellen, HJ., Woolf, CJ., Penninger, JM. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143(4):628-38 (abstract)
 
Neely, GG., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, CP., Keene, AC., Alayari, NN., Yamakawa, H., Elling, U., Berger, C., Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, JA., Imai, Y., Pfeufer, A., Hicks, AA., Pramstaller, PP., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53 (abstract)
 
Oudit, GY., Liu, GC., Zhong, J., Basu, R., Chow, FL., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, JM., Herzenberg, AM., Kassiri, Z., Scholey, JW. (2010). Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 59(2):529-38 (abstract)
 
Paolino, M., Penninger, JM. (2010). Cbl-b in T-cell activation. Semin Immunopathol. 32(2):137-48 (abstract)
 
Pospisilik, JA., Schramek, D., Schnidar, H., Cronin, SJ., Nehme, NT., Zhang, X., Knauf, C., Cani, PD., Aumayr, K., Todoric, J., Bayer, M., Haschemi, A., Puviindran, V., Tar, K., Orthofer, M., Neely, GG., Dietzl, G., Manoukian, A., Funovics, M., Prager, G., Wagner, O., Ferrandon, D., Aberger, F., Hui, CC., Esterbauer, H., Penninger, JM. (2010). Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140(1):148-60 (abstract)
 
Saade, M., Irla, M., Yammine, M., Boulanger, N., Victorero, G., Vincentelli, R., Penninger, JM., Holländer, GA., Chauvet, S., Nguyen, C. (2010). Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 40(2):530-8 (abstract)
 
Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, JA., Lee, HJ., Hanada, R., Joshi, PA., Aliprantis, A., Glimcher, L., Pasparakis, M., Khokha, R., Ormandy, CJ., Widschwendter, M., Schett, G., Penninger, JM. (2010). Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468(7320):98-102 (abstract)
 
Seo, J., Asaoka, Y., Nagai, Y., Hirayama, J., Yamasaki, T., Namae, M., Ohata, S., Shimizu, N., Negishi, T., Kitagawa, D., Kondoh, H., Furutani-Seiki, M., Penninger, JM., Katada, T., Nishina, H. (2010). Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 110(4):1022-37 (abstract)
 
Treml, B., Neu, N., Kleinsasser, A., Gritsch, C., Finsterwalder, T., Geiger, R., Schuster, M., Janzek, E., Loibner, H., Penninger, J., Loeckinger, A. (2010). Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit Care Med. 38(2):596-601 (abstract)
 
Wysocki, J., Ye, M., Rodriguez, E., González-Pacheco, FR., Barrios, C., Evora, K., Schuster, M., Loibner, H., Brosnihan, KB., Ferrario, CM., Penninger, JM., Batlle, D. (2010). Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 55(1):90-8 (abstract)
 
Xu, H., Su, Z., Wu, J., Yang, M., Penninger, JM., Martin, CM., Kvietys, PR., Rui, T. (2010). The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol. 184(3):1492-8 (abstract)
 
Zhong, J., Basu, R., Guo, D., Chow, FL., Byrns, S., Schuster, M., Loibner, H., Wang, XH., Penninger, JM., Kassiri, Z., Oudit, GY. (2010). Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122(7):717-28, 18 p following 728 (abstract)
 
(2009)
 
Blyszczuk, P., Kania, G., Dieterle, T., Marty, RR., Valaperti, A., Berthonneche, C., Pedrazzini, T., Berger, CT., Dirnhofer, S., Matter, CM., Penninger, JM., Lüscher, TF., Eriksson, U. (2009). Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res. 105(9):912-20 (abstract)
 
Camargo, SM., Singer, D., Makrides, V., Huggel, K., Pos, KM., Wagner, CA., Kuba, K., Danilczyk, U., Skovby, F., Kleta, R., Penninger, JM., Verrey, F. (2009). Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology. 136(3):872-82 (abstract)
 
Cronin, SJ., Nehme, NT., Limmer, S., Liegeois, S., Pospisilik, JA., Schramek, D., Leibbrandt, A., Simoes, Rde M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, GG., von Haeseler, A., Ferrandon, D., Penninger, JM. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 325(5938):340-3 (abstract)
 
Fontán-Lozano, A., Romero-Granados, R., del-Pozo-Martín, Y., Suárez-Pereira, I., Delgado-García, JM., Penninger, JM., Carrión, AM. (2009). Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol. 19(1):54-60 (abstract)
 
Galluzzi, L., Aaronson, SA., Abrams, J., Alnemri, ES., Andrews, DW., Baehrecke, EH., Bazan, NG., Blagosklonny, MV., Blomgren, K., Borner, C., Bredesen, DE., Brenner, C., Castedo, M., Cidlowski, JA., Ciechanover, A., Cohen, GM., De Laurenzi, V., De Maria, R., Deshmukh, M., Dynlacht, BD., El-Deiry, WS., Flavell, RA., Fulda, S., Garrido, C., Golstein, P., Gougeon, ML., Green, DR., Gronemeyer, H., Hajnóczky, G., Hardwick, JM., Hengartner, MO., Ichijo, H., Jäättelä, M., Kepp, O., Kimchi, A., Klionsky, DJ., Knight, RA., Kornbluth, S., Kumar, S., Levine, B., Lipton, SA., Lugli, E., Madeo, F., Malomi, W., Marine, JC., Martin, SJ., Medema, JP., Mehlen, P., Melino, G., Moll, UM., Morselli, E., Nagata, S., Nicholson, DW., Nicotera, P., Nuñez, G., Oren, M., Penninger, J., Pervaiz, S., Peter, ME., Piacentini, M., Prehn, JH., Puthalakath, H., Rabinovich, GA., Rizzuto, R., Rodrigues, CM., Rubinsztein, DC., Rudel, T., Scorrano, L., Simon, HU., Steller, H., Tschopp, J., Tsujimoto, Y., Vandenabeele, P., Vitale, I., Vousden, KH., Youle, RJ., Yuan, J., Zhivotovsky, B., Kroemer, G. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 16(8):1093-107 (abstract)
 
Gruber, T., Hermann-Kleiter, N., Hinterleitner, R., Fresser, F., Schneider, R., Gastl, G., Penninger, JM., Baier, G. (2009). PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal. 2(76):ra30 (abstract)
 
Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., Klaere, S., Komnenovic, V., Mimata, H., Yoshimatsu, H., Takahashi, N., von Haeseler, A., Bader, M., Kilic, SS., Ueta, Y., Pifl, C., Narumiya, S., Penninger, JM. (2009). Central control of fever and female body temperature by RANKL/RANK. Nature. 462(7272):505-9 (abstract)
 
Hayer, S., Pundt, N., Peters, MA., Wunrau, C., Kühnel, I., Neugebauer, K., Strietholt, S., Zwerina, J., Korb, A., Penninger, J., Joosten, LA., Gay, S., Rückle, T., Schett, G., Pap, T. (2009). PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 23(12):4288-98 (abstract)
 
Joza, N., Pospisilik, JA., Hangen, E., Hanada, T., Modjtahedi, N., Penninger, JM., Kroemer, G. (2009). AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci. 1171:2-11 (abstract)
 
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, PP., Scholey, JW., Penninger, JM., Oudit, GY. (2009). Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2(5):446-55 (abstract)
 
Köcher, T., Pichler, P., Schutzbier, M., Stingl, C., Kaul, A., Teucher, N., Hasenfuss, G., Penninger, JM., Mechtler, K. (2009). High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res. 8(10):4743-52 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies. Adv Exp Med Biol. 649:100-13 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). ESCI award lecture: from a little mouse to rationale medicine for bone loss. Eur J Clin Invest. 39(10):842-50 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). RANK(L) as a key target for controlling bone loss. Adv Exp Med Biol. 647:130-45 (abstract)
 
Loeser, S., Penninger, J.M. (2009). Regulation of T cell anergy and escape from regulatory T cells suppression by Cbl-b. In: The Epigenetics of Autoimmune disease. Ed. N. Zouali. :pp. 75-94
 
Mizoguchi, T., Muto, A., Udagawa, N., Arai, A., Yamashita, T., Hosoya, A., Ninomiya, T., Nakamura, H., Yamamoto, Y., Kinugawa, S., Nakamura, M., Nakamichi, Y., Kobayashi, Y., Nagasawa, S., Oda, K., Tanaka, H., Tagaya, M., Penninger, JM., Ito, M., Takahashi, N. (2009). Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol. 184(4):541-54 (abstract)
 
Nagatake, T., Fukuyama, S., Kim, DY., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, AM., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, JM., Kunisawa, J., Kiyono, H. (2009). Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 206(11):2351-64 (abstract)
 
Osterreicher, CH., Taura, K., De Minicis, S., Seki, E., Penz-Osterreicher, M., Kodama, Y., Kluwe, J., Schuster, M., Oudit, GY., Penninger, JM., Brenner, DA. (2009). Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 50(3):929-38 (abstract)
 
Oudit, GY., Imai, Y., Kuba, K., Scholey, JW., Penninger, JM. (2009). The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrol Dial Transplant. 24(5):1362-5 (abstract)
 
Oudit, GY., Kassiri, Z., Jiang, C., Liu, PP., Poutanen, SM., Penninger, JM., Butany, J. (2009). SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest. 39(7):618-25 (abstract)
 
Oudit, GY., Penninger, JM. (2009). Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res. 82(2):250-60 (abstract)
 
Paolino, M., Penninger, JM. (2009). E3 ubiquitin ligases in T-cell tolerance. Eur J Immunol. 39(9):2337-44 (abstract)
 
Singer, D., Camargo, SM., Huggel, K., Romeo, E., Danilczyk, U., Kuba, K., Chesnov, S., Caron, MG., Penninger, JM., Verrey, F. (2009). Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. J Biol Chem. 284(30):19953-60 (abstract)
 
Spurrell, DR., Luckashenak, NA., Minney, DC., Chaplin, A., Penninger, JM., Liwski, RS., Clements, JL., West, KA. (2009). Vav1 regulates the migration and adhesion of dendritic cells. J Immunol. 183(1):310-8 (abstract)
 
Tanemura, S., Momose, H., Shimizu, N., Kitagawa, D., Seo, J., Yamasaki, T., Nakagawa, K., Kajiho, H., Penninger, JM., Katada, T., Nishina, H. (2009). Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem. 145(3):345-54 (abstract)
 
(2008)
 
Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, JM., Matsumoto, M., Nitta, T., Takahama, Y., Inoue, J. (2008). The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29(3):423-37 (abstract)
 
Ban, K., Cooper, AJ., Samuel, S., Bhatti, A., Patel, M., Izumo, S., Penninger, JM., Backx, PH., Oudit, GY., Tsushima, RG. (2008). Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res. 103(6):643-53 (abstract)
 
Chavakis, E., Carmona, G., Urbich, C., Göttig, S., Henschler, R., Penninger, JM., Zeiher, AM., Chavakis, T., Dimmeler, S. (2008). Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res. 102(8):942-9 (abstract)
 
Galluzzi, L., Joza, N., Tasdemir, E., Maiuri, MC., Hengartner, M., Abrams, JM., Tavernarakis, N., Penninger, J., Madeo, F., Kroemer, G. (2008). No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15(7):1113-23 (abstract)
 
Garabelli, PJ., Modrall, JG., Penninger, JM., Ferrario, CM., Chappell, MC. (2008). Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 93(5):613-21 (abstract)
 
Hara, H., Ishihara, C., Takeuchi, A., Xue, L., Morris, SW., Penninger, JM., Yoshida, H., Saito, T. (2008). Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 181(2):918-30 (abstract)
 
Haubner, B. J., Neely, G., Pachinger, O., Penninger, J. M., Metzler, B. (2008). PI3Kgamma AKTing during myocardial ischemia and reperfusion. Wiener Klin. Wochenschrift. (15):95-97
 
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, JM., Takayanagi, H., Yokota, Y., Yamada, H., Yoshikai, Y., Inoue, J., Akiyama, T., Takahama, Y. (2008). The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29(3):438-50 (abstract)
 
Imai, Y., Kuba, K., Neely, GG., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, YH., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, JS., Slutsky, AS., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, CJ., Penninger, JM. (2008). Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133(2):235-49 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2008). [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]. Masui. 57(3):302-10 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2008). The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol. 93(5):543-8 (abstract)
 
Joza, N., Galindo, K., Pospisilik, JA., Benit, P., Rangachari, M., Kanitz, EE., Nakashima, Y., Neely, GG., Rustin, P., Abrams, JM., Kroemer, G., Penninger, JM. (2008). The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Cell Death Differ. 15(6):1009-18 (abstract)
 
Kuwana, H., Terada, Y., Kobayashi, T., Okado, T., Penninger, JM., Irie-Sasaki, J., Sasaki, T., Sasaki, S. (2008). The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int. 73(4):430-45 (abstract)
 
Leibbrandt, A., Penninger, J. M. (2008). The role of RANKL in cancer. In: Encyclopedia of Cancer. Ed. Schwab, M. Springer.
 
Leibbrandt, A., Penninger, J. M. (2008). RANK(L) as a key target for controlling bone loss. In: Therapeutic Targets of the TNF Superfamily. Ed. I. Grewal. Landes Bioscience/Eurekah.com.
 
Leibbrandt, A., Penninger, JM. (2008). RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143:123-50 (abstract)
 
Loeser, S., Penninger, J.M. (2008). The Role of the E3 ubiquitin ligase Cbl-b in T-cells signalling and tolerance. In: CBL Proteins. Ed. A. Tsygankov. Nova Science Publishers Inc. :Chapter 9
 
Lovren, F., Pan, Y., Quan, A., Teoh, H., Wang, G., Shukla, PC., Levitt, KS., Oudit, GY., Al-Omran, M., Stewart, DJ., Slutsky, AS., Peterson, MD., Backx, PH., Penninger, JM., Verma, S. (2008). Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 295(4):H1377-84 (abstract)
 
Meixner, A., Zenz, R., Schonthaler, HB., Kenner, L., Scheuch, H., Penninger, JM., Wagner, EF. (2008). Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nat Cell Biol. 10(8):1003-11 (abstract)
 
Oudit, GY., Kassiri, Z., Zhou, J., Liu, QC., Liu, PP., Backx, PH., Dawood, F., Crackower, MA., Scholey, JW., Penninger, JM. (2008). Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res. 78(3):505-14 (abstract)
 
Penninger, J., Imai, Y., Kuba, K. (2008). The discovery of ACE2 and its role in acute lung injury. Exp Physiol. (abstract)
 
Penninger, J.M. (2008). Do genes dream? In: Identitaet(en). Ed. GLOBArt. Springer.
 
Qiao, G., Li, Z., Molinero, L., Alegre, ML., Ying, H., Sun, Z., Penninger, JM., Zhang, J. (2008). T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 28(7):2470-80 (abstract)
 
Raberger, J., Boucheron, N., Sakaguchi, S., Penninger, JM., Ellmeier, W. (2008). Impaired T-cell development in the absence of Vav1 and Itk. Eur J Immunol. 38(12):3530-42 (abstract)
 
Reich, HN., Oudit, GY., Penninger, JM., Scholey, JW., Herzenberg, AM. (2008). Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 74(12):1610-6 (abstract)
 
Wada, T., Stepniak, E., Hui, L., Leibbrandt, A., Katada, T., Nishina, H., Wagner, EF., Penninger, JM. (2008). Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15(1):89-93 (abstract)
 
(2007)
 
Alnaeeli, M., Park, J., Mahamed, D., Penninger, JM., Teng, YT. (2007). Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 22(6):775-80 (abstract)
 
Cronin, SJ., Penninger, JM. (2007). From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev. 220:151-68 (abstract)
 
Feraud, O., Debili, N., Penninger, JM., Kroemer, G. (2007). Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF. Cell Death Differ. 14(2):385-7 (abstract)
 
Fischer, L., Gukovskaya, AS., Penninger, JM., Mareninova, OA., Friess, H., Gukovsky, I., Pandol, SJ. (2007). Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 292(3):G875-86 (abstract)
 
Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, SW., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H., Penninger, JM., Saito, T. (2007). The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 8(6):619-29 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2007). Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cell Mol Life Sci. 64(15):2006-12 (abstract)
 
Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., Leschnik, M., Leibbrandt, A., Markovic, M., Makovic, M., Schwaighofer, J., Beetz, N., Musialek, R., Neely, GG., Komnenovic, V., Kolm, U., Metzler, B., Ricci, R., Hara, H., Meixner, A., Nghiem, M., Chen, X., Dawood, F., Wong, KM., Sarao, R., Cukerman, E., Kimura, A., Hein, L., Thalhammer, J., Liu, PP., Penninger, JM. (2007). Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 101(4):e32-42 (abstract)
 
Liu, L., Puri, KD., Penninger, JM., Kubes, P. (2007). Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 110(4):1191-8 (abstract)
 
Loeser, S., Loser, K., Bijker, MS., Rangachari, M., van der Burg, SH., Wada, T., Beissert, S., Melief, CJ., Penninger, JM. (2007). Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med. 204(4):879-91 (abstract)
 
Loeser, S., Penninger, JM. (2007). The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle. 6(20):2478-85 (abstract)
 
Loeser, S., Penninger, JM. (2007). Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin Immunol. 19(3):206-14 (abstract)
 
Nakamichi, Y., Udagawa, N., Kobayashi, Y., Nakamura, M., Yamamoto, Y., Yamashita, T., Mizoguchi, T., Sato, M., Mogi, M., Penninger, JM., Takahashi, N. (2007). Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 178(1):192-200 (abstract)
 
Nishio, M., Watanabe, K., Sasaki, J., Taya, C., Takasuga, S., Iizuka, R., Balla, T., Yamazaki, M., Watanabe, H., Itoh, R., Kuroda, S., Horie, Y., Förster, I., Mak, TW., Yonekawa, H., Penninger, JM., Kanaho, Y., Suzuki, A., Sasaki, T. (2007). Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 9(1):36-44 (abstract)
 
Oudit, GY., Kassiri, Z., Patel, MP., Chappell, M., Butany, J., Backx, PH., Tsushima, RG., Scholey, JW., Khokha, R., Penninger, JM. (2007). Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 75(1):29-39 (abstract)
 
Pospisilik, JA., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, PD., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., Esterbauer, H., Kozlov, A., Kahn, CR., Kroemer, G., Rustin, P., Burcelin, R., Penninger, JM. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131(3):476-91 (abstract)
 
Rossi, SW., Kim, MY., Leibbrandt, A., Parnell, SM., Jenkinson, WE., Glanville, SH., McConnell, FM., Scott, HS., Penninger, JM., Jenkinson, EJ., Lane, PJ., Anderson, G. (2007). RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med. 204(6):1267-72 (abstract)
 
Séverin, S., Gratacap, MP., Lenain, N., Alvarez, L., Hollande, E., Penninger, JM., Gachet, C., Plantavid, M., Payrastre, B. (2007). Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Invest. 117(4):944-52 (abstract)
 
Shambharkar, PB., Blonska, M., Pappu, BP., Li, H., You, Y., Sakurai, H., Darnay, BG., Hara, H., Penninger, J., Lin, X. (2007). Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 26(7):1794-805 (abstract)
 
Tassi, I., Cella, M., Gilfillan, S., Turnbull, I., Diacovo, TG., Penninger, JM., Colonna, M. (2007). p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity. 27(2):214-27 (abstract)
 
Wong, DW., Oudit, GY., Reich, H., Kassiri, Z., Zhou, J., Liu, QC., Backx, PH., Penninger, JM., Herzenberg, AM., Scholey, JW. (2007). Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol. 171(2):438-51 (abstract)
 
Zhang, L., Anglesio, MS., O'Sullivan, M., Zhang, F., Yang, G., Sarao, R., Mai, PN., Cronin, S., Hara, H., Melnyk, N., Li, L., Wada, T., Liu, PP., Farrar, J., Arceci, RJ., Sorensen, PH., Penninger, JM. (2007). The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9 (abstract)
 
Zuber, AM., Singer, D., Penninger, JM., Rossier, BC., Firsov, D. (2007). Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. J Am Soc Nephrol. 18(6):1672-8 (abstract)
 
(2006)
 
Alnaeeli, M., Penninger, JM., Teng, YT. (2006). Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 177(5):3314-26 (abstract)
 
Atfield, AD., Liu, P., Penninger JM. (2006). The biochemical mechanisms of T-cell anergy Curr. Immunol. Rev.. 2:73-99
 
Brown, D., Yu, BD., Joza, N., Bénit, P., Meneses, J., Firpo, M., Rustin, P., Penninger, JM., Martin, GR. (2006). Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 103(26):9918-23 (abstract)
 
Cheng, HY., Dziema, H., Papp, J., Mathur, DP., Koletar, M., Ralph, MR., Penninger, JM., Obrietan, K. (2006). The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 26(50):12984-95 (abstract)
 
Cheng, H-Y.M, Penninger, JM. (2006). Dream/KchIP/ Calsenilin: a multifunctional player in health and disease. In Neuronal Calcium Sensor Proteins (Philippov, Koch, eds.); Nova Science Publishers. :245-270
 
Cheung, EC., Joza, N., Steenaart, NA., McClellan, KA., Neuspiel, M., McNamara, S., MacLaurin, JG., Rippstein, P., Park, DS., Shore, GC., McBride, HM., Penninger, JM., Slack, RS. (2006). Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 25(17):4061-73 (abstract)
 
Danilczyk, U., Penninger, JM. (2006). Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 98(4):463-71 (abstract)
 
Danilczyk, U., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A., Arya, S., Pospisilik, JA., Singer, D., Camargo, SM., Makrides, V., Ramadan, T., Verrey, F., Wagner, CA., Penninger, JM. (2006). Essential role for collectrin in renal amino acid transport. Nature. 444(7122):1088-91 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM., (2006). The renin angiotensin system in acute respiratory distress syndrome. Drug Discovery Today. 3:225-229
 
Jones, DH., Nakashima, T., Sanchez, OH., Kozieradzki, I., Komarova, SV., Sarosi, I., Morony, S., Rubin, E., Sarao, R., Hojilla, CV., Komnenovic, V., Kong, YY., Schreiber, M., Dixon, SJ., Sims, SM., Khokha, R., Wada, T., Penninger, JM. (2006). Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440(7084):692-6 (abstract)
 
Kim, NS., Kim, HJ., Koo, BK., Kwon, MC., Kim, YW., Cho, Y., Yokota, Y., Penninger, JM., Kong, YY. (2006). Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol. 26(3):1002-13 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 6(3):271-6 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mediated regulation of cardiovascular peptides and its application for treating disease. Experimental Medicine. 24:71-77
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mutant mice. Respiratory Molecular Medicine. 10:38-42
 
Kuba, K., Imai, Y., Rao, S., Jiang, C., Penninger, JM. (2006). Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. J Mol Med (Berl). 84(10):814-20 (abstract)
 
Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, JM., Beissert, S. (2006). Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 12(12):1372-9 (abstract)
 
Marty, RR., Dirnhofer, S., Mauermann, N., Schweikert, S., Akira, S., Hunziker, L., Penninger, JM., Eriksson, U. (2006). MyD88 signaling controls autoimmune myocarditis induction. Circulation. 113(2):258-65 (abstract)
 
Maruyama, K., Takada, Y., Ray, N., Kishimoto, Y., Penninger, JM., Yasuda, H., Matsuo, K. (2006). Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 177(6):3799-805 (abstract)
 
Nakashima T., Penninger, JM. (2006). Chemotactic regulation of cancer cell migration and bone metastases by RANKL. Experimental Medicine. 24:1777-80
 
Oudit, GY., Herzenberg, AM., Kassiri, Z., Wong, D., Reich, H., Khokha, R., Crackower, MA., Backx, PH., Penninger, JM., Scholey, JW. (2006). Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol. 168(6):1808-20 (abstract)
 
Rangachari, M., Mauermann, N., Marty, RR., Dirnhofer, S., Kurrer, MO., Komnenovic, V., Penninger, JM., Eriksson, U. (2006). T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med. 203(8):2009-19 (abstract)
 
Roy, AA., Nunn, C., Ming, H., Zou, MX., Penninger, J., Kirshenbaum, LA., Dixon, SJ., Chidiac, P. (2006). Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem. 281(43):32684-93 (abstract)
 
Sun, H., Kerfant, BG., Zhao, D., Trivieri, MG., Oudit, GY., Penninger, JM., Backx, PH. (2006). Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res. 98(11):1390-7 (abstract)
 
Valdés, G., Neves, LA., Anton, L., Corthorn, J., Chacón, C., Germain, AM., Merrill, DC., Ferrario, CM., Sarao, R., Penninger, J., Brosnihan, KB. (2006). Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies. Placenta. 27(2-3):200-7 (abstract)
 
Vorbach, C., Capecchi, MR., Penninger, JM. (2006). Evolution of the mammary gland from the innate immune system? Bioessays. 28(6):606-16 (abstract)
 
Wada, T., Nakashima, T., Hiroshi, N., Penninger, JM. (2006). RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 12(1):17-25 (abstract)
 
Yamamoto, Y., Udagawa, N., Matsuura, S., Nakamichi, Y., Horiuchi, H., Hosoya, A., Nakamura, M., Ozawa, H., Takaoka, K., Penninger, JM., Noguchi, T., Takahashi, N. (2006). Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand. Endocrinology. 147(7):3366-74 (abstract)
 
Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, JV., Bourne, HR., Devreotes, PN., McCaig, CD., Penninger, JM. (2006). Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442(7101):457-60 (abstract)
 
(2005)
 
Bachmaier, K., Penninger, JM. (2005). Chlamydia and antigenic mimicry. Curr Top Microbiol Immunol. 296:153-63 (abstract)
 
Eriksson, U., Kopf, M., Afanasyeva, M., Penninger, JM. (2005). Models of autoimmune heart disease: a review of current status. Drug Discovery Today: Disease Models, online edition.
 
Eriksson, U., Penninger, JM. (2005). Autoimmune heart failure: new understandings of pathogenesis. Int J Biochem Cell Biol. 37(1):27-32 (abstract)
 
Eriksson, U., Penninger, JM., Kopf, M. (2005). Autoimmune heart disease: from bench to bedside. Drug Discovery Today: Disease Mechanisms, online edition.
 
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., Crackower, MA., Fukamizu, A., Hui, CC., Hein, L., Uhlig, S., Slutsky, AS., Jiang, C., Penninger, JM. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436(7047):112-6 (abstract)
 
Joza, N., Oudit, GY., Brown, D., Bénit, P., Kassiri, Z., Vahsen, N., Benoit, L., Patel, MM., Nowikovsky, K., Vassault, A., Backx, PH., Wada, T., Kroemer, G., Rustin, P., Penninger, JM. (2005). Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 25(23):10261-72 (abstract)
 
Kerfant, BG., Gidrewicz, D., Sun, H., Oudit, GY., Penninger, JM., Backx, PH. (2005). Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res. 96(10):1079-86 (abstract)
 
Kolas, NK., Marcon, E., Crackower, MA., Höög, C., Penninger, JM., Spyropoulos, B., Moens, PB. (2005). Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma. 114(2):92-102 (abstract)
 
Krawczyk, CM., Jones, RG., Atfield, A., Bachmaier, K., Arya, S., Odermatt, B., Ohashi, PS., Penninger, JM. (2005). Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol. 174(3):1472-8 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2005). Angiotensin converting enzyme 2 (ACE2) and SARS infections. Experimental Medicine. 23:2830-5
 
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., Bao, L., Zhang, B., Liu, G., Wang, Z., Chappell, M., Liu, Y., Zheng, D., Leibbrandt, A., Wada, T., Slutsky, AS., Liu, D., Qin, C., Jiang, C., Penninger, JM. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 11(8):875-9 (abstract)
 
Liu, YC., Penninger, J., Karin, M. (2005). Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 5(12):941-52 (abstract)
 
Mahamed, DA., Marleau, A., Alnaeeli, M., Singh, B., Zhang, X., Penninger, JM., Teng, YT. (2005). G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 54(5):1477-86 (abstract)
 
Puri, KD., Doggett, TA., Huang, CY., Douangpanya, J., Hayflick, JS., Turner, M., Penninger, J., Diacovo, TG. (2005). The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood. 106(1):150-7 (abstract)
 
Rangachari, M., Eriksson, U., Vollmann, EH., Penninger, JM. (2005). A novel model for pathogenesis of autoimmune heart failure: the role of dendritic cells. International Congress Series (Uehara Foundation Review). 1285:192-201
 
Ricci, R., Eriksson, U., Oudit, GY., Eferl, R., Akhmedov, A., Sumara, I., Sumara, G., Kassiri, Z., David, JP., Bakiri, L., Sasse, B., Idarraga, MH., Rath, M., Kurz, D., Theussl, HC., Perriard, JC., Backx, P., Penninger, JM., Wagner, EF. (2005). Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev. 19(2):208-13 (abstract)
 
Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, MA., Tanaka, K., Penninger, JM., Yonekawa, H., Suzuki, A., Kanaho, Y. (2005). Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 201(6):859-70 (abstract)
 
Wada, T., Nakashima, T., Oliveira-dos-Santos, AJ., Gasser, J., Hara, H., Schett, G., Penninger, JM. (2005). The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 11(4):394-9 (abstract)
 
Wang, X., Zeng, W., Soyombo, AA., Tang, W., Ross, EM., Barnes, AP., Milgram, SL., Penninger, JM., Allen, PB., Greengard, P., Muallem, S. (2005). Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 7(4):405-11 (abstract)
 
Wilson, LD., Ross, SA., Lepore, DA., Wada, T., Penninger, JM., Thomas, PQ. (2005). Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expr Patterns. 5(3):305-11 (abstract)
 
(2004)
 
Anglesio, MS., Evdokimova, V., Melnyk, N., Zhang, L., Fernandez, CV., Grundy, PE., Leach, S., Marra, MA., Brooks-Wilson, AR., Penninger, J., Sorensen, PH. (2004). Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Hum Mol Genet. 13(18):2061-74 (abstract)
 
Candé, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, E., Spahr, C., Luban, J., Kroemer, RT., Giordanetto, F., Garrido, C., Penninger, JM., Kroemer, G. (2004). AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 23(8):1514-21 (abstract)
 
Cheng, HY., Laviolette, SR., van der Kooy, D., Penninger, JM. (2004). DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci. 19(11):3033-41 (abstract)
 
Cheng, HY., Obrietan, K., Cain, SW., Lee, BY., Agostino, PV., Joza, NA., Harrington, ME., Ralph, MR., Penninger, JM. (2004). Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43(5):715-28 (abstract)
 
Cheng, HY., Penninger, JM. (2004). DREAMing about arthritic pain. Ann Rheum Dis. 63 Suppl 2:ii72-ii75 (abstract)
 
Danilczyk, U., Eriksson, U., Oudit, GY., Penninger, JM. (2004). Physiological roles of angiotensin-converting enzyme 2. Cell Mol Life Sci. 61(21):2714-9 (abstract)
 
Danilczyk, U., Penninger, J. (2004). Hypertension with a grain of salt. Nat Med. 10(11):1163-4 (abstract)
 
Fischer, L., Gukovskaya, AS., Young, SH., Gukovsky, I., Lugea, A., Buechler, P., Penninger, JM., Friess, H., Pandol, SJ. (2004). Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. Am J Physiol Gastrointest Liver Physiol. 287(6):G1200-12 (abstract)
 
Gronski, MA., Boulter, JM., Moskophidis, D., Nguyen, LT., Holmberg, K., Elford, AR., Deenick, EK., Kim, HO., Penninger, JM., Odermatt, B., Gallimore, A., Gascoigne, NR., Ohashi, PS. (2004). TCR affinity and negative regulation limit autoimmunity. Nat Med. 10(11):1234-9 (abstract)
 
Gukovsky, I., Cheng, JH., Nam, KJ., Lee, OT., Lugea, A., Fischer, L., Penninger, JM., Pandol, SJ., Gukovskaya, AS. (2004). Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 126(2):554-66 (abstract)
 
Hara, H., Bakal, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T., Penninger, JM. (2004). The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 200(9):1167-77 (abstract)
 
Jeon, MS., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., Bouchard, D., Jones, R., Gronski, M., Ohashi, P., Wada, T., Bloom, D., Fathman, CG., Liu, YC., Penninger, JM. (2004). Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 21(2):167-77 (abstract)
 
Marra, LE., Zhang, ZX., Joe, B., Campbell, J., Levy, GA., Penninger, J., Zhang, L. (2004). IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. J Immunol. 172(2):1028-35 (abstract)
 
Martin-McCaffrey, L., Willard, FS., Oliveira-dos-Santos, AJ., Natale, DR., Snow, BE., Kimple, RJ., Pajak, A., Watson, AJ., Dagnino, L., Penninger, JM., Siderovski, DP., D'Souza, SJ. (2004). RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 7(5):763-9 (abstract)
 
Matsumoto, G., Kubota, E., Omi, Y., Lee, U., Penninger, JM. (2004). Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. J Immunol. 173(8):4976-84 (abstract)
 
Nishitai, G., Shimizu, N., Negishi, T., Kishimoto, H., Nakagawa, K., Kitagawa, D., Watanabe, T., Momose, H., Ohata, S., Tanemura, S., Asaka, S., Kubota, J., Saito, R., Yoshida, H., Mak, TW., Wada, T., Penninger, JM., Azuma, N., Nishina, H., Katada, T. (2004). Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J Biol Chem. 279(3):1621-6 (abstract)
 
Oudit, GY., Sun, H., Kerfant, BG., Crackower, MA., Penninger, JM., Backx, PH. (2004). The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 37(2):449-71 (abstract)
 
Perfettini, JL., Roumier, T., Castedo, M., Larochette, N., Boya, P., Raynal, B., Lazar, V., Ciccosanti, F., Nardacci, R., Penninger, J., Piacentini, M., Kroemer, G. (2004). NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. J Exp Med. 199(5):629-40 (abstract)
 
Rangachari, M., Penninger, JM. (2004). Negative regulation of T cell receptor signals. Curr Opin Pharmacol. 4(4):415-22 (abstract)
 
Reif, K., Okkenhaug, K., Sasaki, T., Penninger, JM., Vanhaesebroeck, B., Cyster, JG. (2004). Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 173(4):2236-40 (abstract)
 
Vahsen, N., Candé, C., Brière, JJ., Bénit, P., Joza, N., Larochette, N., Mastroberardino, PG., Pequignot, MO., Casares, N., Lazar, V., Feraud, O., Debili, N., Wissing, S., Engelhardt, S., Madeo, F., Piacentini, M., Penninger, JM., Schägger, H., Rustin, P., Kroemer, G. (2004). AIF deficiency compromises oxidative phosphorylation. EMBO J. 23(23):4679-89 (abstract)
 
Wada, T., Joza, N., Cheng, HY., Sasaki, T., Kozieradzki, I., Bachmaier, K., Katada, T., Schreiber, M., Wagner, EF., Nishina, H., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 6(3):215-26 (abstract)
 
Wada, T., Nishina, H., Katada, T., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell cycle progression and cellular senescence. Exper. Med. . 22:1398-400
 
Wada, T., Penninger, JM. (2004). Stress kinase MKK7: savior of cell cycle arrest and cellular senescence. Cell Cycle. 3(5):577-9 (abstract)
 
Wada, T., Penninger, JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23(16):2838-49 (abstract)
 
Wang, X., Huang, G., Luo, X., Penninger, JM., Muallem, S. (2004). Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J Biol Chem. 279(40):41642-9 (abstract)
 
(2003)
 
Brosnihan, KB., Neves, LA., Joyner, J., Averill, DB., Chappell, MC., Sarao, R., Penninger, J., Ferrario, CM. (2003). Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 42(4):749-53 (abstract)
 
Cheng, HY., Penninger, JM. (2003). When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opin Ther Targets. 7(2):249-63 (abstract)
 
Crackower, MA., Kolas, NK., Noguchi, J., Sarao, R., Kikuchi, K., Kaneko, H., Kobayashi, E., Kawai, Y., Kozieradzki, I., Landers, R., Mo, R., Hui, CC., Nieves, E., Cohen, PE., Osborne, LR., Wada, T., Kunieda, T., Moens, PB., Penninger, JM. (2003). Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 300(5623):1291-5 (abstract)
 
Danilczyk, U., Eriksson, U., Crackower, MA., Penninger, JM. (2003). A story of two ACEs. J Mol Med (Berl). 81(4):227-34 (abstract)
 
Eriksson, U., Kurrer, MO., Sonderegger, I., Iezzi, G., Tafuri, A., Hunziker, L., Suzuki, S., Bachmaier, K., Bingisser, RM., Penninger, JM., Kopf, M. (2003). Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med. 197(3):323-31 (abstract)
 
Eriksson, U., Ricci, R., Hunziker, L., Kurrer, MO., Oudit, GY., Watts, TH., Sonderegger, I., Bachmaier, K., Kopf, M., Penninger, JM. (2003). Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med. 9(12):1484-90 (abstract)
 
Giuriato, S., Pesesse, X., Bodin, S., Sasaki, T., Viala, C., Marion, E., Penninger, J., Schurmans, S., Erneux, C., Payrastre, B. (2003). SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 376(Pt 1):199-207 (abstract)
 
Gonzalez-Espinosa, C., Odom, S., Olivera, A., Hobson, JP., Martinez, ME., Oliveira-Dos-Santos, A., Barra, L., Spiegel, S., Penninger, JM., Rivera, J. (2003). Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med. 197(11):1453-65 (abstract)
 
Griffiths, EK., Sanchez, O., Mill, P., Krawczyk, C., Hojilla, CV., Rubin, E., Nau, MM., Khokha, R., Lipkowitz, S., Hui, CC., Penninger, JM. (2003). Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol. 23(21):7708-18 (abstract)
 
Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Griffiths, EK., Krawczyk, C., Bauer, B., D'Acquisto, F., Ghosh, S., Yeh, WC., Baier, G., Rottapel, R., Penninger, JM. (2003). The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18(6):763-75 (abstract)
 
Heximer, SP., Knutsen, RH., Sun, X., Kaltenbronn, KM., Rhee, MH., Peng, N., Oliveira-dos-Santos, A., Penninger, JM., Muslin, AJ., Steinberg, TH., Wyss, JM., Mecham, RP., Blumer, KJ. (2003). Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 111(8):1259 (abstract)
 
Irie-Sasaki, J., Sasaki, T., Penninger, JM. (2003). CD45 regulated signaling pathways. Curr Top Med Chem. 3(7):783-96 (abstract)
 
Jun, JE., Wilson, LE., Vinuesa, CG., Lesage, S., Blery, M., Miosge, LA., Cook, MC., Kucharska, EM., Hara, H., Penninger, JM., Domashenz, H., Hong, NA., Glynne, RJ., Nelms, KA., Goodnow, CC. (2003). Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18(6):751-62 (abstract)
 
Kim, C., Marchal, CC., Penninger, J., Dinauer, MC. (2003). The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 171(8):4425-30 (abstract)
 
Kishimoto, H., Nakagawa, K., Watanabe, T., Kitagawa, D., Momose, H., Seo, J., Nishitai, G., Shimizu, N., Ohata, S., Tanemura, S., Asaka, S., Goto, T., Fukushi, H., Yoshida, H., Suzuki, A., Sasaki, T., Wada, T., Penninger, JM., Nishina, H., Katada, T. (2003). Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 278(19):16595-601 (abstract)
 
Nakashima, T., Wada, T., Penninger, JM. (2003). RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3):280-7 (abstract)
 
Oudit, GY., Crackower, MA., Backx, PH., Penninger, JM. (2003). The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 13(3):93-101 (abstract)
 
Oudit, GY., Crackower, MA., Eriksson, U., Sarao, R., Kozieradzki, I., Sasaki, T., Irie-Sasaki, J., Gidrewicz, D., Rybin, VO., Wada, T., Steinberg, SF., Backx, PH., Penninger, JM. (2003). Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108(17):2147-52 (abstract)
 
Penninger, JM., Kroemer, G. (2003). Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol. 5(2):97-9 (abstract)
 
Saibil, SD., Ohteki, T., White, FM., Luscher, M., Zakarian, A., Elford, A., Shabanowitz, J., Nishina, H., Hugo, P., Penninger, J., Barber, B., Hunt, DF., Ohashi, PS. (2003). Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 33(3):685-96 (abstract)
 
Schmitt, E., Parcellier, A., Gurbuxani, S., Cande, C., Hammann, A., Morales, MC., Hunt, CR., Dix, DJ., Kroemer, RT., Giordanetto, F., Jäättelä, M., Penninger, JM., Pance, A., Kroemer, G., Garrido, C. (2003). Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 63(23):8233-40 (abstract)
 
Suzuki, N., Chen, NJ., Millar, DG., Suzuki, S., Horacek, T., Hara, H., Bouchard, D., Nakanishi, K., Penninger, JM., Ohashi, PS., Yeh, WC. (2003). IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5 (abstract)
 
Suzuki, N., Suzuki, S., Eriksson, U., Hara, H., Mirtosis, C., Chen, NJ., Wada, T., Bouchard, D., Hwang, I., Takeda, K., Fujita, T., Der, S., Penninger, JM., Akira, S., Saito, T., Yeh, WC. (2003). IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol. 171(11):6065-71 (abstract)
 
(2002)
 
Cheng, H.-YM., Penninger, JM. (2002). Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Exp. Rev. Neurotherapeutics. 2:677-89
 
Cheng, HY., Pitcher, GM., Laviolette, SR., Whishaw, IQ., Tong, KI., Kockeritz, LK., Wada, T., Joza, NA., Crackower, M., Goncalves, J., Sarosi, I., Woodgett, JR., Oliveira-dos-Santos, AJ., Ikura, M., van der Kooy, D., Salter, MW., Penninger, JM. (2002). DREAM is a critical transcriptional repressor for pain modulation. Cell. 108(1):31-43 (abstract)
 
Crackower, MA., Oudit, GY., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J., Sah, R., Cheng, HY., Rybin, VO., Lembo, G., Fratta, L., Oliveira-dos-Santos, AJ., Benovic, JL., Kahn, CR., Izumo, S., Steinberg, SF., Wymann, MP., Backx, PH., Penninger, JM. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110(6):737-49 (abstract)
 
Crackower, MA., Sarao, R., Oudit, GY., Yagil, C., Kozieradzki, I., Scanga, SE., Oliveira-dos-Santos, AJ., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, CM., Manoukian, AS., Chappell, MC., Backx, PH., Yagil, Y., Penninger, JM. (2002). Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417(6891):822-8 (abstract)
 
Eriksson, U., Danilczyk, U., Penninger, JM. (2002). Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol. 12(21):R745-52 (abstract)
 
Griffiths, EK., Penninger, JM. (2002). ADAP-ting TCR signaling to integrins. Sci STKE. 2002(127):re3 (abstract)
 
Griffiths, EK., Penninger, JM. (2002). Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol. 14(3):317-22 (abstract)
 
Ito, N., Yokomizo, T., Sasaki, T., Kurosu, H., Penninger, J., Kanaho, Y., Katada, T., Hanaoka, K., Shimizu, T. (2002). Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem. 277(47):44898-904 (abstract)
 
Jones, DH., Kong, YY., Penninger, JM. (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis. 61 Suppl 2:ii32-9 (abstract)
 
Joza, N., Kroemer, G., Penninger, JM. (2002). Genetic analysis of the mammalian cell death machinery. Trends Genet. 18(3):142-9 (abstract)
 
Kim, HJ., Yoon, MJ., Lee, J., Penninger, JM., Kong, YY. (2002). Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta. J Biol Chem. 277(7):5339-44 (abstract)
 
Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, PS., Snapper, S., Alt, F., Penninger, JM. (2002). Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16(3):331-43 (abstract)
 
Kurrer, MO., Kopf, M., Penninger, J., Eriksson, U. (2002). Cytokines that regulate autoimmune myocarditis. Swiss Med Wkly. 132(29-30):408-13 (abstract)
 
Maté, MJ., Ortiz-Lombardía, M., Boitel, B., Haouz, A., Tello, D., Susin, SA., Penninger, J., Kroemer, G., Alzari, PM. (2002). The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 9(6):442-6 (abstract)
 
Matsumoto, G., Tsunematsu, S., Tsukinoki, K., Ohmi, Y., Iwamiya, M., Oliveira-dos-Santos, A., Tone, D., Shindo, J., Penninger, JM. (2002). Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. J Immunol. 169(12):7087-96 (abstract)
 
Opavsky, MA., Martino, T., Rabinovitch, M., Penninger, J., Richardson, C., Petric, M., Trinidad, C., Butcher, L., Chan, J., Liu, PP. (2002). Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 109(12):1561-9 (abstract)
 
Penninger, JM., Bachmaier, K. (2002). Infections and the immune response to cardiac antigens. Book chapter. Epitope recognition since Landsteiner's discovery - 100 years since the discovery of human blood groups (Eibl, M., Mayr, WR., Thorbecke, GJ., eds.). :103-17
 
Roumier, T., Vieira, HL., Castedo, M., Ferri, KF., Boya, P., Andreau, K., Druillennec, S., Joza, N., Penninger, JM., Roques, B., Kroemer, G. (2002). The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death Differ. 9(11):1212-9 (abstract)
 
Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2002). The potential role of CD45 as a drug target. Curr. Topics Med. Chem.. 131:495-501
 
Sasaki, T., Suzuki, A., Sasaki, J., Penninger, JM. (2002). Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem. 131(4):495-501 (abstract)
 
Suzuki, N., Suzuki, S., Duncan, GS., Millar, DG., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, JM., Wesche, H., Ohashi, PS., Mak, TW., Yeh, WC. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416(6882):750-6 (abstract)
 
Tani-Ishii, N., Penninger, JM., Matsumoto, G., Teranaka, T., Umemoto, T. (2002). The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. J Periodontal Res. 37(3):184-91 (abstract)
 
Theill, LE., Boyle, WJ., Penninger, JM. (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 20:795-823 (abstract)
 
Watanabe, T., Nakagawa, K., Ohata, S., Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., Aoki, J., Arai, H., Iwatsubo, T., Mochita, M., Watanabe, T., Satake, M., Ito, Y., Matsuyama, T., Mak, TW., Penninger, JM., Nishina, H., Katada, T. (2002). SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol. 250(2):332-47 (abstract)
 
(2001)
 
Bony, C., Roche, S., Shuichi, U., Sasaki, T., Crackower, MA., Penninger, J., Mano, H., Pucéat, M. (2001). A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol. 152(4):717-28 (abstract)
 
Diao, J., Khine, AA., Sarangi, F., Hsu, E., Iorio, C., Tibbles, LA., Woodgett, JR., Penninger, J., Richardson, CD. (2001). X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem. 276(11):8328-40 (abstract)
 
Griffiths, EK., Krawczyk, C., Kong, YY., Raab, M., Hyduk, SJ., Bouchard, D., Chan, VS., Kozieradzki, I., Oliveira-Dos-Santos, AJ., Wakeham, A., Ohashi, PS., Cybulsky, MI., Rudd, CE., Penninger, JM. (2001). Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science. 293(5538):2260-3 (abstract)
 
Irie-Sasaki, J., Sasaki, T., Matsumoto, W., Opavsky, A., Cheng, M., Welstead, G., Griffiths, E., Krawczyk, C., Richardson, CD., Aitken, K., Iscove, N., Koretzky, G., Johnson, P., Liu, P., Rothstein, DM., Penninger, JM. (2001). CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409(6818):349-54 (abstract)
 
Joza, N., Susin, SA., Daugas, E., Stanford, WL., Cho, SK., Li, CY., Sasaki, T., Elia, AJ., Cheng, HY., Ravagnan, L., Ferri, KF., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, YY., Mak, TW., Zúñiga-Pflücker, JC., Kroemer, G., Penninger, JM. (2001). Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410(6828):549-54 (abstract)
 
Krawczyk, C., Penninger, JM. (2001). Molecular motors involved in T cell receptor clusterings. J Leukoc Biol. 69(3):317-30 (abstract)
 
Krawczyk, C., Penninger, JM. (2001). Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol. 11(5):212-20 (abstract)
 
Loeffler, M., Daugas, E., Susin, SA., Zamzami, N., Metivier, D., Nieminen, AL., Brothers, G., Penninger, JM., Kroemer, G. (2001). Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J. 15(3):758-67 (abstract)
 
Mak, TW., Penninger, JM., Ohashi, PS. (2001). Knockout mice: a paradigm shift in modern immunology. Nat Rev Immunol. 1(1):11-9 (abstract)
 
Miramar, MD., Costantini, P., Ravagnan, L., Saraiva, LM., Haouzi, D., Brothers, G., Penninger, JM., Peleato, ML., Kroemer, G., Susin, SA. (2001). NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem. 276(19):16391-8 (abstract)
 
Osawa, M., Tong, KI., Lilliehook, C., Wasco, W., Buxbaum, JD., Cheng, HY., Penninger, JM., Ikura, M., Ames, JB. (2001). Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 276(44):41005-13 (abstract)
 
Penninger, JM., Irie-Sasaki, J., Sasaki, T., Oliveira-dos-Santos, AJ. (2001). CD45: new jobs for an old acquaintance. Nat Immunol. 2(5):389-96 (abstract)
 
Penninger, JM., Woodgett, J. (2001). Stem cells. PTEN--coupling tumor suppression to stem cells? Science. 294(5549):2116-8 (abstract)
 
Ravagnan, L., Gurbuxani, S., Susin, SA., Maisse, C., Daugas, E., Zamzami, N., Mak, T., Jäättelä, M., Penninger, JM., Garrido, C., Kroemer, G. (2001). Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 3(9):839-43 (abstract)
 
Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2001). New insights into the transmembrane protein tyrosine phosphatase CD45. Int J Biochem Cell Biol. 33(11):1041-6 (abstract)
 
Sasaki, T., Sasaki, J., Suzuki, A., Penninger, JM. (2001). [Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis]. Tanpakushitsu Kakusan Koso. 46(12):1820-9 (abstract)
 
Sasaki, T., Wada, T., Kishimoto, H., Irie-Sasaki, J., Matsumoto, G., Goto, T., Yao, Z., Wakeham, A., Mak, TW., Suzuki, A., Cho, SK., Zuniga-Pflucker, JC., Oliveira-dos-Santos, AJ., Katada, T., Nishina, H., Penninger, JM. (2001). The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J Exp Med. 194(6):757-68 (abstract)
 
Sohal, DS., Nghiem, M., Crackower, MA., Witt, SA., Kimball, TR., Tymitz, KM., Penninger, JM., Molkentin, JD. (2001). Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 89(1):20-5 (abstract)
 
Suzuki, A., Yamaguchi, MT., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A., Higuchi, T., Fukumoto, M., Tsubata, T., Ohashi, PS., Koyasu, S., Penninger, JM., Nakano, T., Mak, TW. (2001). T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 14(5):523-34 (abstract)
 
Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, SK., Jordana, M., Wakeham, A., Boucher, LM., Bouchard, D., Chan, VS., Duncan, G., Odermatt, B., Ho, A., Itie, A., Horan, T., Whoriskey, JS., Pawson, T., Penninger, JM., Ohashi, PS., Mak, TW. (2001). ICOS is essential for effective T-helper-cell responses. Nature. 409(6816):105-9 (abstract)
 
Wada, T., Nakagawa, K., Watanabe, T., Nishitai, G., Seo, J., Kishimoto, H., Kitagawa, D., Sasaki, T., Penninger, JM., Nishina, H., Katada, T. (2001). Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation. J Biol Chem. 276(33):30892-7 (abstract)
 
Yum, HK., Arcaroli, J., Kupfner, J., Shenkar, R., Penninger, JM., Sasaki, T., Yang, KY., Park, JS., Abraham, E. (2001). Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol. 167(11):6601-8 (abstract)
 
(2000)
 
Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, YY., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, PS., Sarosi, I., Nishina, H., Lipkowitz, S., Penninger, JM. (2000). Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403(6766):211-6 (abstract)
 
Bachmaier, K., Le, J., Penninger, JM. (2000). "Catching heart disease": antigenic mimicry and bacterial infections. Nat Med. 6(8):841-2 (abstract)
 
Daugas, E., Susin, SA., Zamzami, N., Ferri, KF., Irinopoulou, T., Larochette, N., Prévost, MC., Leber, B., Andrews, D., Penninger, J., Kroemer, G. (2000). Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 14(5):729-39 (abstract)
 
Fata, JE., Kong, YY., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, RA., Elliott, R., Scully, S., Voura, EB., Lacey, DL., Boyle, WJ., Khokha, R., Penninger, JM. (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103(1):41-50 (abstract)
 
Ferri, KF., Jacotot, E., Blanco, J., Esté, JA., Zamzami, N., Susin, SA., Xie, Z., Brothers, G., Reed, JC., Penninger, JM., Kroemer, G. (2000). Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med. 192(8):1081-92 (abstract)
 
Kong, YY., Boyle, WJ., Penninger, JM. (2000). Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today. 21(10):495-502 (abstract)
 
Kong, YY., Penninger, JM. (2000). Molecular control of bone remodeling and osteoporosis. Exp Gerontol. 35(8):947-56 (abstract)
 
Krawczyk, C., Bachmaier, K., Sasaki, T., Jones, RG., Snapper, SB., Bouchard, D., Kozieradzki, I., Ohashi, PS., Alt, FW., Penninger, JM. (2000). Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13(4):463-73 (abstract)
 
Liu, P., Aitken, K., Kong, YY., Opavsky, MA., Martino, T., Dawood, F., Wen, WH., Kozieradzki, I., Bachmaier, K., Straus, D., Mak, TW., Penninger, JM. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med. 6(4):429-34 (abstract)
 
Matsumoto, G., Omi, Y., Lee, U., Nishimura, T., Shindo, J., Penninger, JM. (2000). Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. Eur J Immunol. 30(12):3723-31 (abstract)
 
Oliveira-Dos-Santos, AJ., Matsumoto, G., Snow, BE., Bai, D., Houston, FP., Whishaw, IQ., Mariathasan, S., Sasaki, T., Wakeham, A., Ohashi, PS., Roder, JC., Barnes, CA., Siderovski, DP., Penninger, JM. (2000). Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A. 97(22):12272-7 (abstract)
 
Penninger, JM., Bachmaier, K. (2000). Review of microbial infections and the immune response to cardiac antigens. J Infect Dis. 181 Suppl 3:S498-504 (abstract)
 
Sasaki, T., Irie-Sasaki, J., Horie, Y., Bachmaier, K., Fata, JE., Li, M., Suzuki, A., Bouchard, D., Ho, A., Redston, M., Gallinger, S., Khokha, R., Mak, TW., Hawkins, PT., Stephens, L., Scherer, SW., Tsao, M., Penninger, JM. (2000). Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature. 406(6798):897-902 (abstract)
 
Sasaki, T., Irie-Sasaki, J., Jones, RG., Oliveira-dos-Santos, AJ., Stanford, WL., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I., Joza, N., Mak, TW., Ohashi, PS., Suzuki, A., Penninger, JM. (2000). Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 287(5455):1040-6 (abstract)
 
Susin, SA., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, KF., Irinopoulou, T., Prévost, MC., Brothers, G., Mak, TW., Penninger, J., Earnshaw, WC., Kroemer, G. (2000). Two distinct pathways leading to nuclear apoptosis. J Exp Med. 192(4):571-80 (abstract)
 
Teng, YT., Nguyen, H., Gao, X., Kong, YY., Gorczynski, RM., Singh, B., Ellen, RP., Penninger, JM. (2000). Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 106(6):R59-67 (abstract)
 
(1999)
 
Bachmaier, K., Neu, N., de la Maza, LM., Pal, S., Hessel, A., Penninger, JM. (1999). Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283(5406):1335-9 (abstract)
 
Bachmaier, K., Neu, N., Yeung, RS., Mak, TW., Liu, P., Penninger, JM. (1999). Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation. 99(14):1885-91 (abstract)
 
Bachmann, MF., Nitschke, L., Krawczyk, C., Tedford, K., Ohashi, PS., Fischer, KD., Penninger, JM. (1999). The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. J Immunol. 163(1):137-42 (abstract)
 
Hakem, A., Sasaki, T., Kozieradzki, I., Penninger, JM. (1999). The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J Exp Med. 189(6):957-68 (abstract)
 
Irwin, MW., Mak, S., Mann, DL., Qu, R., Penninger, JM., Yan, A., Dawood, F., Wen, WH., Shou, Z., Liu, P. (1999). Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. Circulation. 99(11):1492-8 (abstract)
 
Keane, MM., Ettenberg, SA., Nau, MM., Banerjee, P., Cuello, M., Penninger, J., Lipkowitz, S. (1999). cbl-3: a new mammalian cbl family protein. Oncogene. 18(22):3365-75 (abstract)
 
Khan, Q., Penninger, JM., Yang, L., Marra, LE., Kozieradzki, I., Zhang, L. (1999). Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones. J Immunol. 162(10):5860-7 (abstract)
 
Kong, YY., Boyle, WJ., Penninger, JM. (1999). Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol Cell Biol. 77(2):188-93 (abstract)
 
Kong, YY., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., Wong, T., Campagnuolo, G., Moran, E., Bogoch, ER., Van, G., Nguyen, LT., Ohashi, PS., Lacey, DL., Fish, E., Boyle, WJ., Penninger, JM. (1999). Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 402(6759):304-9 (abstract)
 
Kong, YY., Yoshida, H., Sarosi, I., Tan, HL., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, AJ., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, CR., Lacey, DL., Mak, TW., Boyle, WJ., Penninger, JM. (1999). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397(6717):315-23 (abstract)
 
Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, DJ., Penninger, JM. (1999). SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev. 13(7):786-91 (abstract)
 
Lomaga, MA., Yeh, WC., Sarosi, I., Duncan, GS., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, JM., Paige, CJ., Lacey, DL., Dunstan, CR., Boyle, WJ., Goeddel, DV., Mak, TW. (1999). TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13(8):1015-24 (abstract)
 
Lorenzo, HK., Susin, SA., Penninger, J., Kroemer, G. (1999). Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6(6):516-24 (abstract)
 
Nishina, H., Vaz, C., Billia, P., Nghiem, M., Sasaki, T., De la Pompa, JL., Furlonger, K., Paige, C., Hui, C., Fischer, KD., Kishimoto, H., Iwatsubo, T., Katada, T., Woodgett, JR., Penninger, JM. (1999). Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development. 126(3):505-16 (abstract)
 
Oliveira-dos-Santos, AJ., Ho, A., Tada, Y., Lafaille, JJ., Tonegawa, S., Mak, TW., Penninger, JM. (1999). CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. J Immunol. 162(8):4490-5 (abstract)
 
Opavsky, MA., Penninger, J., Aitken, K., Wen, WH., Dawood, F., Mak, T., Liu, P. (1999). Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res. 85(6):551-8 (abstract)
 
Penninger, JM., Crabtree, GR. (1999). The actin cytoskeleton and lymphocyte activation. Cell. 96(1):9-12 (abstract)
 
Penninger, JM., Fischer, KD., Sasaki, T., Kozieradzki, I., Le, J., Tedford, K., Bachmaier, K., Ohashi, PS., Bachmann, MF. (1999). The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. Eur J Immunol. 29(5):1709-18 (abstract)
 
Susin, SA., Lorenzo, HK., Zamzami, N., Marzo, I., Snow, BE., Brothers, GM., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, DR., Aebersold, R., Siderovski, DP., Penninger, JM., Kroemer, G. (1999). Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397(6718):441-6 (abstract)
 
Zhang, J., Shehabeldin, A., da Cruz, LA., Butler, J., Somani, AK., McGavin, M., Kozieradzki, I., dos Santos, AO., Nagy, A., Grinstein, S., Penninger, JM., Siminovitch, KA. (1999). Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 190(9):1329-42 (abstract)
 
(1998)
 
Boyd, R., Kozieradzki, I., Chidgey, A., Mittrücker, HW., Bouchard, D., Timms, E., Kishihara, K., Ong, CJ., Chui, D., Marth, JD., Mak, TW., Penninger, JM. (1998). Receptor-specific allelic exclusion of TCRV alpha-chains during development. J Immunol. 161(4):1718-27 (abstract)
 
Fischer, KD., Kong, YY., Nishina, H., Tedford, K., Marengère, LE., Kozieradzki, I., Sasaki, T., Starr, M., Chan, G., Gardener, S., Nghiem, MP., Bouchard, D., Barbacid, M., Bernstein, A., Penninger, JM. (1998). Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 8(10):554-62 (abstract)
 
Fischer, KD., Tedford, K., Penninger, JM. (1998). Vav links antigen-receptor signaling to the actin cytoskeleton. Semin Immunol. 10(4):317-27 (abstract)
 
Hakem, R., Hakem, A., Duncan, GS., Henderson, JT., Woo, M., Soengas, MS., Elia, A., de la Pompa, JL., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, SA., Lowe, SW., Penninger, JM., Mak, TW. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94(3):339-52 (abstract)
 
Kong, YY., Fischer, KD., Bachmann, MF., Mariathasan, S., Kozieradzki, I., Nghiem, MP., Bouchard, D., Bernstein, A., Ohashi, PS., Penninger, JM. (1998). Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med. 188(11):2099-111 (abstract)
 
Liu, Q., Oliveira-Dos-Santos, AJ., Mariathasan, S., Bouchard, D., Jones, J., Sarao, R., Kozieradzki, I., Ohashi, PS., Penninger, JM., Dumont, DJ. (1998). The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 188(7):1333-42 (abstract)
 
Matsumoto, G., Nghiem, MP., Nozaki, N., Schmits, R., Penninger, JM. (1998). Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity. J Immunol. 160(12):5781-9 (abstract)
 
Molina, TJ., Perrot, JY., Penninger, J., Ramos, A., Audouin, J., Briand, P., Mak, TW., Diebold, J. (1998). Differential requirement for p56lck in fetal and adult thymopoiesis. J Immunol. 160(8):3828-34 (abstract)
 
Nishina, H., Radvanyi, L., Raju, K., Sasaki, T., Kozieradzki, I., Penninger, JM. (1998). Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J Immunol. 161(7):3416-20 (abstract)
 
Oliveira-dos-Santos, AJ., Penninger, JM., Rieker-Geley, T., Matsumoto, G., Mak, TM., Wick, G. (1998). Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol. 28(9):2882-92 (abstract)
 
Penninger, JM., Kroemer, G. (1998). Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv Immunol. 68:51-144 (abstract)
 
Penninger, JM., Mak, TW. (1998). Thymocyte selection in Vav and IRF-1 gene-deficient mice. Immunol Rev. 165:149-66 (abstract)
 
Stambolic, V., Suzuki, A., de la Pompa, JL., Brothers, GM., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, JM., Siderovski, DP., Mak, TW. (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 95(1):29-39 (abstract)
 
Yoshida, H., Kong, YY., Yoshida, R., Elia, AJ., Hakem, A., Hakem, R., Penninger, JM., Mak, TW. (1998). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94(6):739-50 (abstract)
 
Yoshida, H., Nishina, H., Takimoto, H., Marengère, LE., Wakeham, AC., Bouchard, D., Kong, YY., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, PS., Penninger, JM., Crabtree, GR., Mak, TW. (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8(1):115-24 (abstract)
 
(1997)
 
Bachmaier, K., Neu, N., Pummerer, C., Duncan, GS., Mak, TW., Matsuyama, T., Penninger, JM. (1997). iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation. 96(2):585-91 (abstract)
 
Bachmaier, K., Pummerer, C., Kozieradzki, I., Pfeffer, K., Mak, TW., Neu, N., Penninger, JM. (1997). Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. Circulation. 95(3):655-61 (abstract)
 
Kozieradzki, I., Kündig, T., Kishihara, K., Ong, CJ., Chiu, D., Wallace, VA., Kawai, K., Timms, E., Ionescu, J., Ohashi, P., Marth, JD., Mak, TW., Penninger, JM. (1997). T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45. J Immunol. 158(7):3130-9 (abstract)
 
Marengère, LE., Mirtsos, C., Kozieradzki, I., Veillette, A., Mak, TW., Penninger, JM. (1997). Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J Immunol. 159(1):70-6 (abstract)
 
Nishina, H., Bachmann, M., Oliveira-dos-Santos, AJ., Kozieradzki, I., Fischer, KD., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, TW., Woodgett, JR., Ohashi, PS., Penninger, JM. (1997). Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med. 186(6):941-53 (abstract)
 
Nishina, H., Fischer, KD., Radvanyi, L., Shahinian, A., Hakem, R., Rubie, EA., Bernstein, A., Mak, TW., Woodgett, JR., Penninger, JM. (1997). Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385(6614):350-3 (abstract)
 
Penninger, JM., Pummerer, C., Liu, P., Neu, N., Bachmaier, K. (1997). Cellular and molecular mechanisms of murine autoimmune myocarditis. APMIS. 105(1):1-13 (abstract)
 
Penninger, JM., Sirard, C., Mittrücker, HW., Chidgey, A., Kozieradzki, I., Nghiem, M., Hakem, A., Kimura, T., Timms, E., Boyd, R., Taniguchi, T., Matsuyama, T., Mak, TW. (1997). The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity. 7(2):243-54 (abstract)
 
Wallace, VA., Penninger, JM., Kishihara, K., Timms, E., Shahinian, A., Pircher, H., Kündig, TM., Ohashi, PS., Mak, TW. (1997). Alterations in the level of CD45 surface expression affect the outcome of thymic selection. J Immunol. 158(7):3205-14 (abstract)
 
Waterhouse, P., Bachmann, MF., Penninger, JM., Ohashi, PS., Mak, TW. (1997). Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur J Immunol. 27(8):1887-92 (abstract)
 
Yao, Z., Diener, K., Wang, XS., Zukowski, M., Matsumoto, G., Zhou, G., Mo, R., Sasaki, T., Nishina, H., Hui, CC., Tan, TH., Woodgett, JP., Penninger, JM. (1997). Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem. 272(51):32378-83 (abstract)
 
(1996)
 
Amakawa, R., Hakem, A., Kundig, TM., Matsuyama, T., Simard, JJ., Timms, E., Wakeham, A., Mittruecker, HW., Griesser, H., Takimoto, H., Schmits, R., Shahinian, A., Ohashi, P., Penninger, JM., Mak, TW. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 84(4):551-62 (abstract)
 
Liu, P., Martino, T., Opavsky, MA., Penninger, J. (1996). Viral myocarditis: balance between viral infection and immune response. Can J Cardiol. 12(10):935-43 (abstract)
 
Penninger, JM., Wallace, VA., Molina, T., Mak, TW. (1996). Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck). J Immunol. 157(12):5359-66 (abstract)
 
Pummerer, CL., Grässl, G., Sailer, M., Bachmaier, KW., Penninger, JM., Neu, N. (1996). Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells. Lab Invest. 74(5):845-52 (abstract)
 
Pummerer, CL., Luze, K., Grässl, G., Bachmaier, K., Offner, F., Burrell, SK., Lenz, DM., Zamborelli, TJ., Penninger, JM., Neu, N. (1996). Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J Clin Invest. 97(9):2057-62 (abstract)
 
Yeung, RS., Penninger, JM., Kündig, T., Khoo, W., Ohashi, PS., Kroemer, G., Mak, TW. (1996). Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock. Eur J Immunol. 26(5):1074-82 (abstract)
 
(1995)
 
Liu, P., Penninger, J., Aitken, K., Sole, M., Mak, T. (1995). The role of transgenic knockout models in defining the pathogenesis of viral heart disease. Eur Heart J. 16 Suppl O:25-7 (abstract)
 
Penninger, JM., Timms, E., Shahinian, A., Jezo-Bremond, A., Nishina, H., Ionescu, J., Hedrick, SM., Mak, TW. (1995). Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells. J Immunol. 155(8):3847-55 (abstract)
 
Penninger, JM., Wen, T., Timms, E., Potter, J., Wallace, VA., Matsuyama, T., Ferrick, D., Sydora, B., Kronenberg, M., Mak, TW. (1995). Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice. Nature. 375(6528):241-4 (abstract)
 
Rieker, T., Penninger, J., Romani, N., Wick, G. (1995). Chicken thymic nurse cells: an overview. Dev Comp Immunol. 19(4):281-9 (abstract)
 
Wallace, VA., Kawai, K., Levelt, CN., Kishihara, K., Molina, T., Timms, E., Pircher, H., Penninger, J., Ohashi, PS., Eichmann, K. (1995). T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 25(5):1312-8 (abstract)
 
Waterhouse, P., Penninger, JM., Timms, E., Wakeham, A., Shahinian, A., Lee, KP., Thompson, CB., Griesser, H., Mak, TW. (1995). Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270(5238):985-8 (abstract)
 
(1994)
 
Ferrick, DA., Gemmell-Hori, L., Sydora, B., Mulvania, T., Penninger, JM., Kronenberg, M., Mak, TW. (1994). Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice. Int Rev Immunol. 11(4):295-304 (abstract)
 
Kimura, T., Nakayama, K., Penninger, J., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilcek, J., Mak, TW. (1994). Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science. 264(5167):1921-4 (abstract)
 
Koh, DR., Ho, A., Rahemtulla, A., Penninger, J., Mak, TW. (1994). Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells. Eur J Immunol. 24(9):2250-3 (abstract)
 
Penninger, JM., Mak, TW. (1994). Signal transduction, mitotic catastrophes, and death in T-cell development. Immunol Rev. 142:231-72 (abstract)
 
Penninger, JM., Wallace, VA., Timms, E., Mak, TW. (1994). Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. Eur J Immunol. 24(5):1102-8 (abstract)
 
Penninger, J., Rieker, T., Romani, N., Klima, J., Salvenmoser, W., Dietrich, H., Stössel, H., Wick, G. (1994). Ultrastructural analysis of thymic nurse cell epithelium. Eur J Immunol. 24(1):222-8 (abstract)
 
Yeung, RS., Penninger, J., Mak, TW. (1994). T-cell development and function in gene-knockout mice. Curr Opin Immunol. 6(2):298-307 (abstract)
 
Yeung, RS., Penninger, JM., Kündig, TM., Law, Y., Yamamoto, K., Kamikawaji, N., Burkly, L., Sasazuki, T., Flavell, R., Ohashi, PS., Mak, TW. (1994). Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. J Exp Med. 180(5):1911-20 (abstract)
 
(1993)
 
Kishihara, K., Penninger, J., Wallace, VA., Kündig, TM., Kawai, K., Wakeham, A., Timms, E., Pfeffer, K., Ohashi, PS., Thomas, ML. (1993). Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 74(1):143-56 (abstract)
 
Penninger, J., Kishihara, K., Molina, T., Wallace, VA., Timms, E., Hedrick, SM., Mak, TW. (1993). Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science. 260(5106):358-61 (abstract)
 
Penninger, JM., Neu, N., Timms, E., Wallace, VA., Koh, DR., Kishihara, K., Pummerer, C., Mak, TW. (1993). The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. J Exp Med. 178(5):1837-42 (abstract)
 
Penninger, JM., Wallace, VA., Kishihara, K., Mak, TW. (1993). The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunol Rev. 135:183-214 (abstract)
 
Rieker, T., Penninger, J., Hala, K., Cooper, MD., Wick, G. (1993). In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes. Eur J Immunol. 23(4):904-10 (abstract)
 
Wallace, VA., Penninger, J., Mak, TW. (1993). CD4, CD8 and tyrosine kinases in thymic selection. Curr Opin Immunol. 5(2):235-40 (abstract)
 
Yeung, RS., Penninger, J., Mak, TW. (1993). Genetically modified animals and immunodeficiency. Curr Opin Immunol. 5(4):585-94 (abstract)
 
(1992)
 
Penninger, J., Wick, G. (1992). Thymic nurse cell lymphocytes react against self major histocompatibility complex. Eur J Immunol. 22(1):79-83 (abstract)
 
Wallace, VA., Fung-Leung, WP., Timms, E., Gray, D., Kishihara, K., Loh, DY., Penninger, J., Mak, TW. (1992). CD45RA and CD45RBhigh expression induced by thymic selection events. J Exp Med. 176(6):1657-63 (abstract)
 
Wallace, VA., Rahemtulla, A., Timms, E., Penninger, J., Mak, TW. (1992). CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. J Exp Med. 176(5):1459-63 (abstract)
 
(1991)
 
Cheng, SH., Penninger, JM., Ferrick, DA., Molina, TJ., Wallace, VA., Mak, TW. (1991). Biology of murine gamma delta T cells. Crit Rev Immunol. 11(3-4):145-66 (abstract)
 
Fedecka-Bruner, B., Penninger, J., Vaigot, P., Lehmann, A., Martínez, C., Kroemer, G. (1991). Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo. Dev Immunol. 1(3):237-42 (abstract)
 
Penninger, J. (1991). [Phenotypic and functional analysis of thymic nurse cell (TNC)-lymphocytes]. Wien Klin Wochenschr. 103(2):45-50 (abstract)
 
Penninger, J., Wallace, VA., Kishihara, K., Molina, T., Krause, H., Mak, TW. (1991). Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors. Exp Clin Immunogenet. 8(2):57-74 (abstract)
 
Wick, G., Rieker, T., Penninger, J. (1991). Thymic nurse cells: a site for positive selection and differentiation of T cells. Curr Top Microbiol Immunol. 173:99-105 (abstract)
 
(1989)
 
Penninger, J., Klima, J., Kroemer, G., Dietrich, H., Hala, K., Wick, G. (1989). Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency. Dev Comp Immunol. 13(4):313-27 (abstract)
 

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