Publications

(2016)
 
Leithner, A., Eichner, A., Müller, J., Reversat, A., Brown, M., Schwarz, J., Merrin, J., de Gorter, DJ., Schur, F., Bayerl, J., de Vries, I., Wieser, S., Hauschild, R., Lai, FP., Moser, M., Kerjaschki, D., Rottner, K., Small, JV., Stradal, TE., Sixt, M. (2016). Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nat Cell Biol. 18(11):1253-1259 (abstract)
 
(2015)
 
Nakajima, K., Zhu, K., Sun, YH., Hegyi, B., Zeng, Q., Murphy, CJ., Small, JV., Chen-Izu, Y., Izumiya, Y., Penninger, JM., Zhao, M. (2015). KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 6:8532 (abstract)
 
Small, JV. (2015). Pushing with actin: from cells to pathogens. Biochem Soc Trans. 43(1):84-91 (abstract)
 
(2014)
 
Mertz, KD., Pathria, G., Wagner, C., Saarikangas, J., Sboner, A., Romanov, J., Gschaider, M., Lenz, F., Neumann, F., Schreiner, W., Nemethova, M., Glassmann, A., Lappalainen, P., Stingl, G., Small, JV., Fink, D., Chin, L., Wagner, SN. (2014). MTSS1 is a metastasis driver in a subset of human melanomas. Nat Commun. 5:3465 (abstract)
 
Mueller, J., Pfanzelter, J., Winkler, C., Narita, A., Le Clainche, C., Nemethova, M., Carlier, MF., Maeda, Y., Welch, MD., Ohkawa, T., Schmeiser, C., Resch, GP., Small, JV. (2014). Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion. PLoS Biol. 12(1):e1001765 (abstract)
 
(2013)
 
Dang, I., Gorelik, R., Sousa-Blin, C., Derivery, E., Guérin, C., Linkner, J., Nemethova, M., Dumortier, JG., Giger, FA., Chipysheva, TA., Ermilova, VD., Vacher, S., Campanacci, V., Herrada, I., Planson, AG., Fetics, S., Henriot, V., David, V., Oguievetskaia, K., Lakisic, G., Pierre, F., Steffen, A., Boyreau, A., Peyriéras, N., Rottner, K., Zinn-Justin, S., Cherfils, J., Bièche, I., Alexandrova, AY., David, NB., Small, JV., Faix, J., Blanchoin, L., Gautreau, A. (2013). Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature. 503(7475):281-4 (abstract)
 
Elsayad, K., Urich, A., Tan, PS., Nemethova, M., Small, JV., Unterrainer, K., Heinze, KG. (2013). Spectrally coded optical nanosectioning (SpecON) with biocompatible metal-dielectric-coated substrates. Proc Natl Acad Sci U S A. 110(50):20069-74 (abstract)
 
Koestler, SA., Steffen, A., Nemethova, M., Winterhoff, M., Luo, N., Holleboom, JM., Krupp, J., Jacob, S., Vinzenz, M., Schur, F., Schlüter, K., Gunning, PW., Winkler, C., Schmeiser, C., Faix, J., Stradal, TE., Small, JV., Rottner, K. (2013). Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin. Mol Biol Cell. 24(18):2861-75 (abstract)
 
Steffen, A., Ladwein, M., Dimchev, GA., Hein, A., Schwenkmezger, L., Arens, S., Ladwein, KI., Margit Holleboom, J., Schur, F., Victor Small, J., Schwarz, J., Gerhard, R., Faix, J., Stradal, TE., Brakebusch, C., Rottner, K. (2013). Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation. J Cell Sci. 126(Pt 20):4572-88 (abstract)
 
(2012)
 
Flynn, KC., Hellal, F., Neukirchen, D., Jacob, S., Tahirovic, S., Dupraz, S., Stern, S., Garvalov, BK., Gurniak, C., Shaw, AE., Meyn, L., Wedlich-Söldner, R., Bamburg, JR., Small, JV., Witke, W., Bradke, F. (2012). ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain. Neuron. 76(6):1091-107 (abstract)
 
Narita, A., Mueller, J., Urban, E., Vinzenz, M., Small, JV., Maéda, Y. (2012). Direct determination of actin polarity in the cell. J Mol Biol. 419(5):359-68 (abstract)
 
Vinzenz, M., Nemethova, M., Schur, F., Mueller, J., Narita, A., Urban, E., Winkler, C., Schmeiser, C., Koestler, SA., Rottner, K., Resch, GP., Maeda, Y., Small, JV. (2012). Actin branching in the initiation and maintenance of lamellipodia. J Cell Sci. 125(Pt 11):2775-85 (abstract)
 
Weichsel, J., Urban, E., Small, JV., Schwarz, US. (2012). Reconstructing the orientation distribution of actin filaments in the lamellipodium of migrating keratocytes from electron microscopy tomography data. Cytometry A. 81(6):496-507 (abstract)
 
Winkler, C., Vinzenz, M., Small, JV., Schmeiser, C. (2012). Actin filament tracking in electron tomograms of negatively stained lamellipodia using the localized radon transform. J Struct Biol. 178(1):19-28 (abstract)
 
(2011)
 
Breitsprecher, D., Kiesewetter, AK., Linkner, J., Vinzenz, M., Stradal, TE., Small, JV., Curth, U., Dickinson, RB., Faix, J. (2011). Molecular mechanism of Ena/VASP-mediated actin-filament elongation. EMBO J. 30(3):456-67 (abstract)
 
Breitsprecher, D., Koestler, SA., Chizhov, I., Nemethova, M., Mueller, J., Goode, BL., Small, JV., Rottner, K., Faix, J. (2011). Cofilin cooperates with fascin to disassemble filopodial actin filaments. J Cell Sci. 124(Pt 19):3305-18 (abstract)
 
Oelkers, JM., Vinzenz, M., Nemethova, M., Jacob, S., Lai, FP., Block, J., Szczodrak, M., Kerkhoff, E., Backert, S., Schlüter, K., Stradal, TE., Small, JV., Koestler, SA., Rottner, K. (2011). Microtubules as platforms for assaying actin polymerization in vivo. PLoS One. 6(5):e19931 (abstract)
 
Resch, GP., Brandstetter, M., Pickl-Herk, AM., Königsmaier, L., Wonesch, VI., Urban, E. (2011). Immersion freezing of biological specimens: rationale, principles, and instrumentation. Cold Spring Harb Protoc. 2011(7):778-82 (abstract)
 
Small, J.V., Winkler, C., Vinzenz, M. and Schmeiser, S (2011). Reply: Visualizing branched actin filaments in lamellipodia by electron tomography Nature Cell Biology. doi:10.1038/ncb2322
 
(2010)
 
Resch, GP., Urban, E., Jacob, S. (2010). The actin cytoskeleton in whole mount preparations and sections. Methods Cell Biol. 96:529-64 (abstract)
 
Small, JV. (2010). Dicing with dogma: de-branching the lamellipodium. Trends Cell Biol. 20(11):628-33 (abstract)
 
Small, J.V. and Rottner, K.R (2010). Elementary Cellular Processes Driven by Actin Assembly: Lamellipodia and Filopodia In “Actin-based Motility” Ed by M.F. Carlier, Springer Science. :pp 3-33
 
Urban, E., Jacob, S., Nemethova, M., Resch, GP., Small, JV. (2010). Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol. 12(5):429-35 (abstract)
 
(2009)
 
Colombelli, J., Besser, A., Kress, H., Reynaud, EG., Girard, P., Caussinus, E., Haselmann, U., Small, JV., Schwarz, US., Stelzer, EH. (2009). Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. J Cell Sci. 122(Pt 10):1665-79 (abstract)
 
Koestler, SA., Rottner, K., Lai, F., Block, J., Vinzenz, M., Small, JV. (2009). F- and G-actin concentrations in lamellipodia of moving cells. PLoS One. 4(3):e4810 (abstract)
 
Lai, FP., Szczodrak, M., Oelkers, JM., Ladwein, M., Acconcia, F., Benesch, S., Auinger, S., Faix, J., Small, JV., Polo, S., Stradal, TE., Rottner, K. (2009). Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases. Mol Biol Cell. 20(14):3209-23 (abstract)
 
Vallotton, P., Small, JV. (2009). Shifting views on the leading role of the lamellipodium in cell migration: speckle tracking revisited. J Cell Sci. 122(Pt 12):1955-8 (abstract) (fulltext)
 
(2008)
 
Auinger, S., Small, JV. (2008). Correlated light and electron microscopy of the cytoskeleton. Methods Cell Biol. 88:257-72 (abstract)
 
Block, J., Stradal, TE., Hänisch, J., Geffers, R., Köstler, SA., Urban, E., Small, JV., Rottner, K., Faix, J. (2008). Filopodia formation induced by active mDia2/Drf3. J Microsc. 231(3):506-17 (abstract)
 
Breitsprecher, D., Kiesewetter, AK., Linkner, J., Urbanke, C., Resch, GP., Small, JV., Faix, J. (2008). Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation. EMBO J. 27(22):2943-54 (abstract)
 
Efimov, A., Schiefermeier, N., Grigoriev, I., Ohi, R., Brown, MC., Turner, CE., Small, JV., Kaverina, I. (2008). Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci. 121(Pt 2):196-204 (abstract)
 
Koestler, SA., Auinger, S., Vinzenz, M., Rottner, K., Small, JV. (2008). Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front. Nat Cell Biol. 10(3):306-13 (abstract)
 
Lai, FP., Szczodrak, M., Block, J., Faix, J., Breitsprecher, D., Mannherz, HG., Stradal, TE., Dunn, GA., Small, JV., Rottner, K. (2008). Arp2/3 complex interactions and actin network turnover in lamellipodia. EMBO J. 27(7):982-92 (abstract)
 
Nemethova, M., Auinger, S., Small, JV. (2008). Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella. J Cell Biol. 180(6):1233-44 (abstract)
 
Oelz, D., Schmeiser, C., Small, JV. (2008). Modeling of the actin-cytoskeleton in symmetric lamellipodial fragments. Cell Adh Migr. 2(2):117-26 (abstract)
 
Scott, RS., Li, Z., Paulin, D., Uvelius, B., Small, JV., Arner, A. (2008). Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder. Am J Physiol Cell Physiol. 295(2):C324-31 (abstract)
 
Small, JV. (2008). Facing up to Mena: Tes(ting) times for EVH1 domains. Nat Cell Biol. 10(2):118-20 (abstract)
 
Small, JV., Auinger, S., Nemethova, M., Koestler, S., Goldie, KN., Hoenger, A., Resch, GP. (2008). Unravelling the structure of the lamellipodium. J Microsc. 231(3):479-85 (abstract)
 
(2007)
 
Efimov, A., Kharitonov, A., Efimova, N., Loncarek, J., Miller, PM., Andreyeva, N., Gleeson, P., Galjart, N., Maia, AR., McLeod, IX., Yates, JR., Maiato, H., Khodjakov, A., Akhmanova, A., Kaverina, I. (2007). Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev Cell. 12(6):917-30 (abstract)
 
(2006)
 
Caspani, EM., Echevarria, D., Rottner, K., Small JV. (2006). Live imaging of glioblastoma cells in brain tissue shows requirement of actin bundles for migration. Neuron Glia Biology. 2:105-14
 
Caspani, EM., Echevarria, D., Rottner, K., Small, JV. (2006). Live imaging of glioblastoma cells in brain tissue shows requirement of actin bundles for migration. Neuron Glia Biol. 2(2):105-14 (abstract)
 
Jenzora, A., Behrendt, B., Small, JV., Wehland, J., Stradal, TE. (2006). PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett. 580(12):455-63 (abstract)
 
Prast, J., Gimona, M., Small, JV. (2006). Immunofluorescence microscopy of the cytoskeleton: combination with GFP tags. A laboratory Handbook III (J.E. Celis, ed.). 1:557-61
 
Resch, GP., Small, JV., Goldie, KN. (2006). Electron Microscopy of Extracted Cytoskeletons: Negative Staining, Cryoelectron Microscopy and Correlation with Light Microscopy. Cell Biology - A Laboratory Handbook (J. E. Celis, ed.).
 
Small, JV., Glotzer, G. (2006). Editorial overview; Cell structure and Dynamics. Current Opinion in Cell Biology. 18:1-3
 
Steffen, A., Faix, J., Resch, GP., Linkner, J., Wehland, J., Small, JV., Rottner, K., Stradal, TE. (2006). Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell. 17(6):2581-91 (abstract)
 
(2005)
 
Balzac, F., Avolio, M., Degani, S., Kaverina, I., Torti, M., Silengo, L., Small, JV., Retta, SF. (2005). E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J Cell Sci. 118(Pt 20):4765-83 (abstract)
 
Ehrenreiter, K., Piazzolla, D., Velamoor, V., Sobczak, I., Small, JV., Takeda, J., Leung, T., Baccarini, M. (2005). Raf-1 regulates Rho signaling and cell migration. J Cell Biol. 168(6):955-64 (abstract)
 
Jenzora, A., Behrendt, B., Small, JV., Wehland, J., Stradal, TE. (2005). PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett. 579(2):455-63 (abstract)
 
Rid, R., Schiefermeier, N., Grigoriev, I., Small, JV., Kaverina, I. (2005). The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells. Cell Motil Cytoskeleton. 61(3):161-71 (abstract)
 
Small, JV., Kaverina, I. (2005). Polarized cell motility: microtubules show the way. Cell Migration in Development and Disease (Wedlich, D., ed). :15-31
 
Small, JV., Resch, GP. (2005). The comings and goings of actin: coupling protrusion and retraction in cell motility. Curr Opin Cell Biol. 17(5):517-23 (abstract)
 
(2004)
 
Small, JV., Kaverina, I. (2004). Polarized cell motility: microtubules show the way. Cell Migration (Wedlich, D., ed). :15-31
 
Small, JV., Vignal, E. (2004). Cell Migration. Encyclopedia of Biological Chemistry (Lennarz, W., Lane, MD., eds.). 1:356-61
 
Yanagisawa, M., Kaverina, IN., Wang, A., Fujita, Y., Reynolds, AB., Anastasiadis, PZ. (2004). A novel interaction between kinesin and p120 modulates p120 localization and function. J Biol Chem. 279(10):9512-21 (abstract)
 
(2003)
 
Gimona, M., Kaverina, I., Resch, GP., Vignal, E., Burgstaller, G. (2003). Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol Biol Cell. 14(6):2482-91 (abstract)
 
Hoogenraad, CC., Wulf, P., Schiefermeier, N., Stepanova, T., Galjart, N., Small, JV., Grosveld, F., de Zeeuw, CI., Akhmanova, A. (2003). Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. EMBO J. 22(22):6004-15 (abstract)
 
Kaverina, I., Stradal, TE., Gimona, M. (2003). Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains. J Cell Sci. 116(Pt 24):4915-24 (abstract)
 
Krylyshkina, O., Anderson, KI., Kaverina, I., Upmann, I., Manstein, DJ., Small, JV., Toomre, DK. (2003). Nanometer targeting of microtubules to focal adhesions. J Cell Biol. 161(5):853-9 (abstract)
 
Nakagawa, H., Miki, H., Nozumi, M., Takenawa, T., Miyamoto, S., Wehland, J., Small, JV. (2003). IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. J Cell Sci. 116(Pt 12):2577-83 (abstract)
 
Small, JV., Kaverina, I. (2003). Microtubules meet substrate adhesions to arrange cell polarity. Curr Opin Cell Biol. 15(1):40-7 (abstract)
 
Vignal, E., Resch, GP. (2003). Shedding light and electrons on the lamellipodium: imaging the motor of crawling cells. Biotechniques. 34(4):780-4, 786, 788-9 (abstract)
 
(2000)
 
Oliferenko, S., Kaverina, I., Small, JV., Huber, LA. (2000). Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth. J Cell Biol. 148(6):1159-64 (abstract)
 
(1999)
 
Rottner, K., Behrendt, B., Small, JV., Wehland, J. (1999). VASP dynamics during lamellipodia protrusion. Nat Cell Biol. 1(5):321-2 (abstract)
 

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