Bon-Kyoung Koo

Homeostatic regulation of adult stem cells

  • Homeostatic turnover in adult tissues is governed by the interplay of a multitude of signalling pathways. Upon tissue damage, adult stem cells rapidly proliferate to restore the loss and reinstate homeostasis; regulatory signalling that governs proliferation and differentiation of stem cells enable this damage response. De-regulation of these processes on the other hand results in either hyperplasia or loss of stem cells. Dr Koo investigates the role of an important class of modulators – E3 ubiquitin ligases – in tissue homeostasis. He has found two important regulators – Mib1 and RNF43. Mib1 has a crucial role in Notch ligand activation in niche cells and RNF43 attenuates Wnt activation in intestinal stem cells. His research focuses on additional E3 ubiquitin ligases that have an important role in stem cell – niche interactions in adult tissues.

  • Contact:

    Bon-Kyoung Koo
    Groupleader at IMBA from October 2017
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Selected Publications

Koo, BK., van Es, JH., van den Born, M., Clevers, H. (2015). Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proc Natl Acad Sci U S A. 112(24):7548-50 (abstract)
Schwank, G., Koo, BK., Sasselli, V., Dekkers, JF., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, CK., Nieuwenhuis, EE., Beekman, JM., Clevers, H. (2013). Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell. 13(6):653-8 (abstract)
Stange, DE., Koo, BK., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, JH., Peters, PJ., van Es, JH., van de Wetering, M., Mills, JC., Clevers, H. (2013). Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell. 155(2):357-68 (abstract)
Koo, BK., Spit, M., Jordens, I., Low, TY., Stange, DE., van de Wetering, M., van Es, JH., Mohammed, S., Heck, AJ., Maurice, MM., Clevers, H. (2012). Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 488(7413):665-9 (abstract)
Koo, BK., Lim, HS., Song, R., Yoon, MJ., Yoon, KJ., Moon, JS., Kim, YW., Kwon, MC., Yoo, KW., Kong, MP., Lee, J., Chitnis, AB., Kim, CH., Kong, YY. (2005). Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development. 132(15):3459-70 (abstract)

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