Scientific News

April 11, 2017

Tuberculosis: Researchers Uncover how Bacteria Burst our Cells

Scientists based in Vienna unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis.

March 29, 2017

Unique genome architectures after fertilisation in single-cell embryos

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo. Their findings have recently been published in the journal Nature. The team of researchers (from three continents) have discovered that the egg and sperm genomes that co-exist in the single-cell embryo or zygote have a unique structure compared to other interphase cells. Understanding this specialized chromatin “ground state” has the potential to provide insights into the yet mysterious process of epigenetic reprogramming to totipotency, the ability to give rise to all cell types.

March 10, 2017

Life scientists move into the mechanisms of self-organization in small brain-like structures

How close to reality are brain organoids, and which molecular mechanisms underlie the remarkable self-organizing capacities of tissues? Researchers already have succeeded in growing so-called “cerebral organoids” in a dish - clusters of cells that self-organize into small brain-like structures. Juergen Knoblich and colleagues have now further characterized these organoids and publish their results today in The EMBO Journal. They demonstrate that, like in the human brain, so-called forebrain organizing centers orchestrate developmental processes in the organoid, and that organoids recapitulate the timing of neuronal differentiation events found in human brains.

January 19, 2017

Scientists initiate first ethical guidelines for organs cultivated in vitro

In the latest edition of the professional journal “Science”, Jürgen Knoblich, a leading authority on stem cells and deputy director of the IMBA (Institute for Molecular Biotechnology of the Austrian Academy of Sciences), together with international experts, presents a first ethical guideline for research into human organ models. In the article, he also argues for critical and responsible engagement with the new technology.

January 03, 2017

IMBA – The year in review: 2016 brought top-level research funding and scientific milestones

In 2016, IMBA – Institute of Molecular Biotechnology at the Austrian Academy of Sciences received the prestigious “Proof of Concept” grant from the European Research Council (ERC) as well as two fellowships in the renowned EMBO Young Investigator Programme. A series of scientific achievements could pave the way for new treatment options in the future, including the possible prevention of breast cancer, new treatments for deadly fungal infections, and improvements in assisted reproduction.

The Vienna Biocenter in the third district of Vienna has established itself as the premier location for life sciences in Central Europe and is a world-leading international bio-medical research center.

 

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